Cell-free DNA in the plasma of patients with systemic sclerosis

被引:0
作者
Marta Mosca
Tiziana Giuliano
Giovanna Cuomo
Marica Doveri
Chiara Tani
Michele Curcio
Giuseppina Abignano
Francesca De Feo
Laura Bazzichi
Alessandra Della Rossa
Gabriele Valentini
Stefano Bombardieri
机构
[1] University of Pisa,Rheumatology Unit, Department of Internal Medicine
[2] Second University of Napoli,Rheumatology Unit
[3] U.O. Immunoematologia 2-Azienda Ospedaliero-Universitaria Pisana,undefined
来源
Clinical Rheumatology | 2009年 / 28卷
关键词
Biomarkers; Cell-free DNA; Disease activity; Plasma cell-free DNA; Scleroderma; Systemic autoimmune diseases;
D O I
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摘要
The aim of the present study was to evaluate the concentration of cell-free DNA (cf-DNA) in the plasma of patients with systemic sclerosis (SSc) and to examine the correlation of cf-DNA with clinical variables of the disease. The study population consisted of 122 SSc patients and 16 healthy controls. Epidemiological and clinical data were collected by direct assessment. The β-globin gene was used to determine the total amount of DNA in the plasma by real-time quantitative PCR analysis. cf-DNA was found in all patients (mean concentration 1,420.7 copies/ml) and controls (mean concentration 1,462.5), with no significant difference. In SSc patients, no correlation was found between cf-DNA and the type of organ involvement, but patients with active disease presented significantly higher cf-DNA concentrations than those with inactive disease (p < 0.05). Our data suggest that cf-DNA could provide a useful biomarker for the assessment of disease activity in SSc patients.
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页码:1437 / 1440
页数:3
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