Antibacterial properties of l-amino acid oxidase: mechanisms of action and perspectives for therapeutic applications

被引：0
作者：
Kosuke Kasai
Takashi Ishikawa
Toshiya Nakamura
Tomisato Miura
机构：
[1] Hirosaki University,Department of Pathologic Analysis, Division of Medical Life Sciences, Graduate School of Health Sciences
[2] Hirosaki University,Department of Biomedical Sciences, Division of Medical Life Sciences, Graduate School of Health Sciences
来源：
Applied Microbiology and Biotechnology | 2015年 / 99卷
关键词：
Antibacterial protein; -amino acid oxidase; Multidrug-resistant bacteria; Hydrogen peroxide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Venom, the mucus layer covering the body surface, ink glands, mammary glands, milk, and various animal secretory functions as both a physical and chemical defense barrier against bacteria and virus infections. Previously, several studies reported that l-amino acid oxidases (LAAOs) present in animal secretary fluids have strong antimicrobial activities and selective cytotoxic activities against Gram-positive and Gram-negative bacteria, various pathogenic bacteria, viruses, and parasite species. These LAAOs catalyze oxidative deamination of an l-amino acid substrate with the generation of hydrogen peroxide. The antibacterial activity of LAAOs is completely inhibited by catalase; thus, LAAOs kill bacteria by the hydrogen peroxide generated from the oxidation of l-amino acid substrates. This review focuses on the selective, specific, and local antibacterial actions of various LAAOs that may be used as novel therapeutic agents against infectious diseases. LAAOs that are suitable leads for combating multidrug-resistant bacterial infections are also studied.
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页码：7847 / 7857
页数：10
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共 423 条
  • [1] Aloush V(2006)Multidrug-resistant Antimicrob Agents Chemother 50 43-48
  • [2] Navon-Venezia S(2006): risk factors and clinical impact Apoptosis 11 1439-1451
  • [3] Seigman-Igra Y(2008)Mechanisms of cell death induction by L-amino acid oxidase, a major component of ophidian venom Yeast 25 349-357
  • [4] Cabili S(2005)Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Lancet Infect Dis 5 653-663
  • [5] Carmeli Y(2004)Methicillin-resistant Cell Death Differ 11 608-617
  • [6] Ande SR(1997)Hydrogen peroxide produced by Proc Natl Acad Sci U S A 94 2507-2512
  • [7] Kommoju PR(1982) ink toxin kills tumor cells independent of apoptosis via peroxiredoxin I sensitive pathways Mol Cell Biochem 49 143-149
  • [8] Draxl S(1982), an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis Antimicrob Agents Chemother 21 210-215
  • [9] Murkovic M(2010)Hydrogen peroxide mediated killing of bacteria Infection 38 41-46
  • [10] Macheroux P(2010)Common R-plasmids in Toxicon 55 795-804
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