The Mechanism of Presynaptic Long-Term Depression Mediated by Group I Metabotropic Glutamate Receptors

被引：0
作者：
Yuansheng Tan
Nobuaki Hori
David O. Carpenter
机构：
[1] University at Albany,Department of Environmental Health and Toxicology, School of Public Health
来源：
Cellular and Molecular Neurobiology | 2003年 / 23卷
关键词：
hippocampus; metabotropic glutamate receptors; calcium; presynaptic; ionophoretic responses; DHPG; AMPA; NMDA; kainate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
1. Metabotropic glutamate receptors (mGluRs) are known to play a role in synaptic plasticity. In a study of rat hippocampal brain slices, we find that a brief perfusion of a group I mGluR agonist, (S)-3,5-dihydroxyphenylglycine (DHPG), induced a robust long-term depression (DHPG-LTD) in area CA1.
引用
收藏
页码：187 / 203
页数：16
相关论文
共 201 条
  • [1] Aiba A.(1994)Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice Cell 79 377-388
  • [2] Kano M.(1999)Metabotropic glutamate receptors: Electrophysiological properties and role in plasticity Brain Res. Rev. 29 83-120
  • [3] Chen C.(1999)A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning Learn. Mem. 6 138-152
  • [4] Stanton M. E.(1992)Metabotropic receptors and ‘slow’ excitatory actions of glutamate agonists in the hippocampus Trends Neurosci. 15 92-96
  • [5] Fox G. D.(1991)Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus J. Physiol (Lond.) 444 687-701
  • [6] Herrup K.(1992)Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn Mol. Pharmacol. 42 192-196
  • [7] Zwingman T. A.(1994)Postsynaptic induction and presynaptic expression of hippocampal long-term depression Science 264 1148-1152
  • [8] Tonegawa S.(1999)Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus Curr. Opin. Neurobiol. 9 299-304
  • [9] Anwyl R.(1994)The nitric oxide–cyclic GMP pathway and synaptic depression in rat hippocampal slices Eur. J. Neurosci. 6 1528-1535
  • [10] Balschun D.(1999)Induction of LTD by activation of group I mGluR in the dentate gyrus Neuropharmacology 38 1597-1606
12345678910