MTA Family of Transcriptional Metaregulators in Mammary Gland Morphogenesis and Breast Cancer

被引:0
作者
Rajesh R. Singh
Rakesh Kumar
机构
[1] The University of Texas,Molecular and Cellular Oncology
[2] M.D. Anderson Cancer Center,undefined
来源
Journal of Mammary Gland Biology and Neoplasia | 2007年 / 12卷
关键词
Mammary gland; Hormones; Cancer; Metastasis; Metastasis tumor antigen; Transcriptional coregulator;
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学科分类号
摘要
Since breast cancer and its associated metastasis are a global health problem and a major cause of mortality among women, research efforts to understand the development, morphogenesis, and functioning of the mammary gland are a high priority. Myriad signaling pathways, transcription factors, and associated transcriptional coregulators have been identified in both normal functioning and neoplastic transformation of the mammary gland. The discovery of the metastasis tumor antigen 1 (MTA1) gene, its overexpression in cancer and metastasis and its subsequent identification as an integral part of the chromatin remodeling complex heralded extensive research on its physiological role. Subsequent identification of additional gene family members, namely MTA1s, MTA2, and MTA3, and their functions in the cell has resulted in the establishment of the significance of the MTA family. The role of these proteins in modulating hormonal responses in normal mammary glands and in breast cancer has resulted in their identification as important molecular markers and potential therapeutic targets.
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页码:115 / 125
页数:10
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