Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population Obesity

被引：9

作者：

Ngwa E.N. ^{[1
,2
]}

Sobngwi E. ^{[1
,2
,3
,4
]}

Atogho-Tiedeu B. ^{[1
,2
]}

Noubiap J.J.N. ^{[5
,6
]}

Donfack O.S. ^{[1
,2
]}

Guewo-Fokeng M. ^{[1
,2
]}

Mofo E.P.M. ^{[1
,2
]}

Fosso P.P. ^{[1
,2
]}

Djahmeni E. ^{[4
]}

Djokam-Dadjeu R. ^{[1
,2
]}

Evehe M.-S. ^{[1
,2
]}

Aminkeng F. ^{[7
]}

Mbacham W.F. ^{[1
,8
]}

Mbanya J.C. ^{[2
,3
,4
]}

机构：

[1] Department of Biochemistry, Faculty of Science, University of Yaoundé i, Yaoundé

[2] Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé i, Yaoundé

[3] Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé i, Yaoundé

[4] National Obesity Center, Yaoundé Central Hospital, Yaoundé

[5] Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town

[6] Medical Diagnostic Center, Yaoundé

[7] Canadian Pharmacogenomics Network for Drug Safety (CPNDS), Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver

[8] Laboratory for Public Health Research Biotechnologies, Biotechnology Center, University of Yaoundé i, Yaoundé

来源：

BMC Research Notes | / 8卷 / 1期

关键词：

Cameroon; Obesity; Sub-Saharan Africa; Transcription factor 7-like 2 (TCF7L2);

D O I：

10.1186/s13104-015-1661-3

中图分类号：

学科分类号：

摘要：

Background: The transcription factor 7-like 2 (TCF7L2) is one of the genes that have been identified as possible determinants of diabetes which is associated with obesity. Data on the genetic causes of obesity in sub-Saharan African populations are very scares. The aim of this study was to assess the association between the transcription factor 7-like 2 (TCF7L2) gene polymorphism (rs12255372 G/T) and obesity and weight-related traits in a Cameroonian population. Methods: A case-control study was conducted on 35 obese and 30 non-obese Cameroonian adults. TCF7L2 rs12255372 genotypes were determined using PCR-RFLP and correlated with BMI and weight-related traits. Results: No significant association was observed between the rs12255372 T allele (χ2 = 0.0684, p = 0.79) or the TT genotype (χ2 = 0.372, p = 0.54) of the TCF7L2 gene and obesity in the Cameroonian population. However, amongst the weight-related traits, triglycerides were significantly associated with the T risk allele of the TCF7L2 gene (p = 0.012). Conclusion: This study on Cameroonian subjects replicates the absence of association between the TCF7L2 rs12255372 variant and obesity as observed in European and American populations. © 2015 Ngwa et al.

引用

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