Role of cancer cell-stroma interaction in invasive growth of cancer cells

被引：39
作者：
Hiroaki Kataoka
Hiroyuki Tanaka
Koki Nagaike
Shuichiro Uchkama
Hiroshi Itoh
机构：
[1] Second Department of Pathology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki
来源：
Human Cell | 2003年 / 16卷 / 1期
关键词：
CD147; EMMPRIN; HAI-1; hepatocyte growth factor; HGF activator; invasion; matriptase; metastasis;
D O I：
10.1111/j.1749-0774.2003.tb00123.x
中图分类号：
学科分类号：
摘要：
Invasive growth is one of the hallmarks of cancer malignancy. To date, a significant body of evidence is accumulating in favor of the notion that invasive growth results from the cross-talk between cancer cells and the host stromal cells, comprising fibroblasts (myofibroblasts), endothelial cells, and leukocytes, all of which are themselves invasive. In this review we describe cross-talk between invasive cancer cells and host stromal fibroblasts and an impact of pericellular microenvironment on the invasive phenotype of cancer cells, focusing on two molecules, extracellular matrix metalloproteinase inducer (EMMPRIN, also known as tumor cell-derived collagenase stimulatoty factor, basigin, CD147) and hepatocyte growth factor (HGF, also known as scatter factor). Both molecules are deeply involved in the regulation of invasion-associated cellular activities, such as pencellular proteolysis, migration and ectopic sunrival of cancer cells. © 2003, Society and Springer Japan.
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页码：1 / 14
页数：13
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共 89 条
[1]  
Dvorak H.F., Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing, N. Engl. J. Med., 315, pp. 1650-1659, (1986)
[2]  
Liotta L.A., Kohn E.C., The microenvironment of the tumour-host interface, Nature, 411, pp. 375-379, (2001)
[3]  
Trusolino L., Comoglio P.M., Scatter-factor and semaphoring receptors: Cell signaling for invasive growth, Nat. Rev. Cancer, 2, pp. 289-300, (2002)
[4]  
Vihnen P., Kahari V.M., Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets, Int. J. Cancer, 99, pp. 157-166, (2002)
[5]  
Sternlicht M.D., Werb Z., How matrix metalloproteinases regulate cell behavior, Annu. Rev. Cell Dev. Biol., 17, pp. 463-516, (2001)
[6]  
Kataoka H., Uchino H., Iwamura T., Et al., Enhanced tumor growth and invasiveness in vivo by a carboxy-terminal fragment of α1-proteinase inhibitor generated by matrix metalloproteinase: A possible modulatory role in natural killer cytotoxicity, Am. J. Pathol., 154, pp. 457-468, (1999)
[7]  
Basset P., Bellocq J.P., Wolf C., Et al., A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas, Nature, 348, pp. 699-704, (1990)
[8]  
Toole B.P., Emmprin (CD 147), a cell surface regulator of matrix metalloproteinase production and function, Curr Top Dev Biol., 54, pp. 371-389, (2003)
[9]  
Ellis S.M., Nabeshima K., Biswas C., Monoclonal antibody preparation and purification of a tumor cell collagenase stimulatory factor, Cancer Res., 49, pp. 3385-3391, (1989)
[10]  
Kataoka H., DeCastro R., Zucker S., Et al., Tumor cell-derived collagenase-stimulatory factor increases expression of interstitial collagenase, stromelysin, and 72-kDa gelatinase, Cancer Res., 53, pp. 3154-3158, (1993)
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