Engineering tumors with 3D scaffolds

被引:0
作者
Claudia Fischbach
Ruth Chen
Takuya Matsumoto
Tobias Schmelzle
Joan S Brugge
Peter J Polverini
David J Mooney
机构
[1] School of Engineering and Applied Sciences,Department of Biomedical Engineering
[2] Harvard University,Department of Oromaxillofacial Regeneration
[3] Cornell University,Department of Cell Biology
[4] Osaka University,undefined
[5] Harvard Medical School,undefined
[6] School of Dentistry,undefined
[7] University of Michigan,undefined
[8] 1011 North University,undefined
来源
Nature Methods | 2007年 / 4卷
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摘要
Microenvironmental conditions control tumorigenesis and biomimetic culture systems that allow for in vitro and in vivo tumor modeling may greatly aid studies of cancer cells' dependency on these conditions. We engineered three-dimensional (3D) human tumor models using carcinoma cells in polymeric scaffolds that recreated microenvironmental characteristics representative of tumors in vivo. Strikingly, the angiogenic characteristics of tumor cells were dramatically altered upon 3D culture within this system, and corresponded much more closely to tumors formed in vivo. Cells in this model were also less sensitive to chemotherapy and yielded tumors with enhanced malignant potential. We assessed the broad relevance of these findings with 3D culture of other tumor cell lines in this same model, comparison with standard 3D Matrigel culture and in vivo experiments. This new biomimetic model may provide a broadly applicable 3D culture system to study the effect of microenvironmental conditions on tumor malignancy in vitro and in vivo.
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页码:855 / 860
页数:5
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