Oxidative Stress, Aging, and Short Peptides

被引：0

作者：

Kuznik B.I. ^{[1
,2
]}

Linkova N.S. ^{[3
,4
,5
]}

Ivko O.M. ^{[3
]}

机构：

[1] Department of Normal Physiology, Chita State Medical Academy, Ministry of Health of the Russian Federation, Chita

[2] “Health Academy” Innovation Clinic, Chita

[3] Department of Biogerontology, Research Center St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg

[4] Department of Therapy, Geriatrics, and Antiaging Medicine, Academy of Postgraduate Education, Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies, Federal Medical Biological Agency, Moscow

[5] “The Aging Challenge” Laboratory, Belgorod State National Research University, Belgorod

来源：

Neuroscience and Behavioral Physiology | 2022年 / 52卷 / 1期

关键词：

aging; neurodegenerative diseases; oxidative stress; short peptides;

D O I：

10.1007/s11055-022-01219-1

中图分类号：

学科分类号：

摘要：

This article reviews oxidative stress as one of the mechanisms impairing the functions of cells, organs, and tissues. Aging is associated with reductions in the activities of the enzymes of the antioxidant system. Reactive oxygen species formed in oxidant stress damage DNA, RNA, proteins, and lipids, leading to cell apoptosis. Neurodegenerative changes can develop in conditions of oxidant stress and mitochondrial dysfunction. A potential direction in the treatment of neurodegenerative pathology consists of using antioxidants such as melatonin or the short peptides AEDG and KE. Peptide AEDG stimulates endogenous melatonin synthesis as the body ages, while peptides AEDG and KE have antioxidant and geroprotective properties, normalizing telomere length and preventing cell apoptosis. Studies of oxidative stress at the cell, organ, and tissue levels are important for gerontology and the search for novel approaches to the treatment of neurodegenerative diseases. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.

引用

页码：183 / 189

页数：6

共 54 条

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