Cytomegalovirus pneumonitis, activated prothrombin time prolongation and subacute thyroiditis after unrelated allogeneic bone marrow transplantation

被引：0
作者：
C Kawano
K Muroi
T Akioka
T Izumi
Y Kodera
K Ozawa
机构：
[1] Jichi Medical School,Division of Cell Transplantation and Transfusion
[2] Jichi Medical School,Department of Hematology
[3] Japanese Red Cross First Hospital,Division of Hematology, Department of Internal Medicine
来源：
Bone Marrow Transplantation | 2000年 / 26卷
关键词：
bone marrow transplantation; antithymocyte globulin; viral infection; CD4; cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A 22-year-old female with acute myeloid leukemia (AML) in complete remission received a conditioning regimen containing antithymocyte globulin for an unrelated bone marrow transplant (BMT). After BMT, the patient suffered from cytomegalovirus (CMV) pneumonitis with markedly high levels of CMV antigenemia, activated prothrombin time (APTT) prolongation, and subacute thyroiditis. Recovery of CD4+ cells was delayed as long as 1 year after BMT. An association between these three episodes and viral infection due to the delayed recovery of CD4+ cells is suggested. Bone Marrow Transplantation (2000) 26, 1347–1349.
引用
收藏
页码：1347 / 1349
页数：2
相关论文
共 56 条
[1]  
Meyers JD(1986)Risk factors for cytomegalovirus infection after human marrow transplantation J Infect Dis 153 478-488
[2]  
Flournoy N(1993)Risk factors for cytomegalovirus infection in BMT recipients transfused exclusively with seronegative blood products Bone Marrow Transplant 11 209-214
[3]  
Thomas ED(1990)Cytomegalovirus excretion as a predictor of cytomegalovirus disease after marrow transplantation: importance of cytomegalovirus viremia J Infect Dis 162 373-380
[4]  
Rubie H(1997)Association of specific cytomegalovirus genotypes with death from myelosuppression after marrow transplantation Blood 90 2097-2102
[5]  
Attal M(1990)Cytomegalovirus antigenemia Rev Infect Dis 12 734-744
[6]  
Campardou AM(1989)Cytomegalovirus antigenemia as a useful marker of symptomatic cytomegalovirus infection after renal transplantation-a report of 130 consecutive patients Transplantation 48 991-995
[7]  
Meyers JD(1985)Marrow transplantation from related donors other than HLA-identical siblings New Engl J Med 313 765-771
[8]  
Ljungman P(1993)Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program New Engl J Med 328 593-602
[9]  
Fisher LD(1999)Analysis of 500 bone marrow transplants from unrelated donors (UR-BMT) facilitated by the Japan Marrow Donor Program: confirmation of UR-BMT as a standard therapy for patients with leukemia and aplastic anemia Bone Marrow Transplant 24 995-1003
[10]  
Torok-Storb B(1993)Infection, thyroid disease, and autoimmunity Endocr Rev 14 107-120
123456