Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

[1] Chen W(2016)Cancer statistics in China, 2015 CA Cancer J Clin 66 115-132

[2] Zheng R(2008)Sorafenib in Advanced Hepatocellular Carcinoma New England Journal of Medicine 359 378-390

[3] Baade PD(2018)Sorafenib and fluvastatin synergistically alleviate hepatic fibrosis via inhibiting the TGFβ1/Smad3 pathway Digestive and Liver Disease 50 381-388

[4] Zhang S(2017)Targeting KDM1A attenuates Wnt/β-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma Cancer Letters 398 12-21

[5] Zeng H(2016)Inhibition of the Wnt/β-catenin signaling pathway improves the anti-tumor effects of sorafenib against hepatocellular carcinoma Cancer Letters 381 58-66

[6] Bray F(2018)Hepatocellular carcinoma The Lancet 391 1301-1314

[7] Llovet Josep M.(2014)Overexpression of the Nek2 kinase in colorectal cancer correlates with beta-catenin relocalization and shortened cancer-specific survival Journal of Surgical Oncology 110 828-838

[8] Ricci Sergio(2017)Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2 Journal of Clinical Investigation 127 3075-3089

[9] Mazzaferro Vincenzo(2014)Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism Oncogene 34 1220-1230

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[1] Chen W(2016)Cancer statistics in China, 2015 CA Cancer J Clin 66 115-132

[2] Zheng R(2008)Sorafenib in Advanced Hepatocellular Carcinoma New England Journal of Medicine 359 378-390

[3] Baade PD(2018)Sorafenib and fluvastatin synergistically alleviate hepatic fibrosis via inhibiting the TGFβ1/Smad3 pathway Digestive and Liver Disease 50 381-388

[4] Zhang S(2017)Targeting KDM1A attenuates Wnt/β-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma Cancer Letters 398 12-21

[5] Zeng H(2016)Inhibition of the Wnt/β-catenin signaling pathway improves the anti-tumor effects of sorafenib against hepatocellular carcinoma Cancer Letters 381 58-66

[6] Bray F(2018)Hepatocellular carcinoma The Lancet 391 1301-1314

[7] Llovet Josep M.(2014)Overexpression of the Nek2 kinase in colorectal cancer correlates with beta-catenin relocalization and shortened cancer-specific survival Journal of Surgical Oncology 110 828-838

[8] Ricci Sergio(2017)Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2 Journal of Clinical Investigation 127 3075-3089

[9] Mazzaferro Vincenzo(2014)Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism Oncogene 34 1220-1230

[10] Hilgard Philip(undefined)undefined undefined undefined undefined-undefined