Nerve growth factor acts via retinoic acid synthesis to stimulate neurite outgrowth

被引：0
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作者：
Jonathan Corcoran
Malcolm Maden
机构：
[1] Developmental Biology Research Centre,
[2] The Randall Institute,undefined
[3] King's College London,undefined
来源：
Nature Neuroscience | 1999年 / 2卷
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摘要：
Nerve growth factor (NGF) stimulates neurite outgrowth from cultured adult dorsal root ganglia (DRG)1, and the vitamin A derivative all-trans-retinoic acid (tRA) induces neurite outgrowth from various embryonic sources, including DRG2,3. Are such similarities in effects of NGF and tRA because they are both components of the same genetic cascade leading to neurite outgrowth? tRA upregulates low-and high-affinity NGF receptors3,4 and induces the transcription of NGF itself5, suggesting that tRA may be upstream of NGF, but we show the converse, namely, that NGF is upstream of tRA.
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页码：307 / 308
页数：1
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