Transformation of B cell lymphoma to histiocytic sarcoma: Somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation

被引：24

作者：

Bassarova A. ^{[1
]}

Trøen G. ^{[1
]}

Fosså A. ^{[2
]}

Ikonomou I.M. ^{[1
]}

Beiske K. ^{[1
]}

Nesland J.M. ^{[1
]}

Delabie J. ^{[1
]}

机构：

[1] Department of Pathology, Oslo University Hospital-The Norwegian Radium Hospital, University of Oslo

[2] Department of Oncology, Oslo University Hospital-The Norwegian Radium Hospital, University of Oslo, Oslo

来源：

Journal of Hematopathology | 2009年 / 2卷 / 3期

关键词：

B-cell; Histiocytic; Lymphoma; PAX-5; Sarcoma; Transdifferentiation;

D O I：

10.1007/s12308-009-0031-2

中图分类号：

学科分类号：

摘要：

Transdifferentiation of B cell lymphoma of germinal center cell origin to histiocytic sarcoma has recently been described but is a rare occurrence. The cause for loss of B cell differentiation in these lymphomas is unknown. We investigated whether somatic hypermutation of the PAX-5 gene, a transcription factor that is important for maintaining B cell identity and is frequently mutated in B cell lymphomas of germinal center cell origin, might be a cause for loss of PAX-5 expression and thus B cell phenotype. However, no somatic hypermutation of the PAX-5 gene was detected in the two cases we studied. The molecular basis for transdifferentiation of B cell lymphoma to histiocytic sarcoma remains therefore unresolved. © Springer-Verlag 2009.

引用

页码：135 / 141

页数：6