A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis (APPAC trial)

[1] Addiss DG(1990)The epidemiology of appendicitis and appendectomy in the United States Am J Epidemiol 132 910-925

[2] Shaffer N(2004)National hospital discharge survey Adv Data 2006 1-19

[3] Fowler BS(2011)Changing incidence of acute appendicitis and nonspecific abdominal pain between 1987 and 2007 in Finland World J Surg 35 731-738

[4] Tauxe RV(2006)Is it safe to delay appendectomy in adults with acute appendicitis? Ann Surg 244 656-660

[5] DeFrances CJ(2011)Appendectomy versus antibiotic treatment for acute appendicitis Cochrane Database Syst Rev 9 CD008359-221

[6] Podgornik MN(2011)Surgery versus conservative antibiotic treatment in acute appendicitis: a systematic review and meta-analysis of randomized controlled trials Dig Surg 28 210-683

[7] Ilves I(2011)Use of antibiotics alone for treatment of uncomplicated acute appendicitis: a systematic review and meta-analysis Surgery 150 673-84

[8] Paajanen HE(2012)Meta-analysis of randomized trials comparing antibiotic therapy with appendectomy for acute uncomplicated (no abscess or phlegmon) appendicitis Surg Infect (Larchmt) 13 74-209

[9] Herzig KH(2010)Antibiotic therapy versus appendectomy for acute appendicitis: a meta-analysis World J Surg 34 199-488

[10] Fagerstrom A(2012)Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials BMJ 344 e2156-127

[1] Addiss DG(1990)The epidemiology of appendicitis and appendectomy in the United States Am J Epidemiol 132 910-925

[2] Shaffer N(2004)National hospital discharge survey Adv Data 2006 1-19

[3] Fowler BS(2011)Changing incidence of acute appendicitis and nonspecific abdominal pain between 1987 and 2007 in Finland World J Surg 35 731-738

[4] Tauxe RV(2006)Is it safe to delay appendectomy in adults with acute appendicitis? Ann Surg 244 656-660

[5] DeFrances CJ(2011)Appendectomy versus antibiotic treatment for acute appendicitis Cochrane Database Syst Rev 9 CD008359-221

[6] Podgornik MN(2011)Surgery versus conservative antibiotic treatment in acute appendicitis: a systematic review and meta-analysis of randomized controlled trials Dig Surg 28 210-683

[7] Ilves I(2011)Use of antibiotics alone for treatment of uncomplicated acute appendicitis: a systematic review and meta-analysis Surgery 150 673-84

[8] Paajanen HE(2012)Meta-analysis of randomized trials comparing antibiotic therapy with appendectomy for acute uncomplicated (no abscess or phlegmon) appendicitis Surg Infect (Larchmt) 13 74-209

[9] Herzig KH(2010)Antibiotic therapy versus appendectomy for acute appendicitis: a meta-analysis World J Surg 34 199-488

[10] Fagerstrom A(2012)Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials BMJ 344 e2156-127