Combination Pharmacotherapy for Treatment of Overactive Bladder (OAB)

被引：0
作者：
Ahmed El-Zawahry
机构：
[1] The University of Toledo,
来源：
Current Urology Reports | 2019年 / 20卷
关键词：
Overactive bladder (OAB); Urinary urgency; Combination therapy for OAB;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Overactive bladder syndrome (OAB) negatively affects the quality of life of patients and their interactions with society. Treatment of OAB starts with behavioral modification and then pharmacotherapy using monotherapy with either antimuscarinics or β3 agonists. The third-line more invasive approaches are the next treatment option currently recommended. Both antimuscarinic agents and β3 agonists work through a different molecular pathway. This brings up the potential of having an additive effect when using a combination treatment for patients with OAB. Currently, the potential for using combination therapy to treat OAB in patients who had no improvement with a monotherapy approach before we attempt a more invasive approach is being explored. Several studies have shown the benefits of combination therapy which will be an additional option to the tools to treat OAB.
引用
收藏
相关论文
共 335 条
  • [1] Abrams P(1988)The standardisation of terminology of lower urinary tract function. The International Continence Society Committee on Standardisation of Terminology Scand J Urol Nephrol Suppl 114 5-19
  • [2] Blaivas JG(2002)The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society Neurourol Urodyn 21 167-178
  • [3] Stanton SL(2004)Defining overactive bladder: epidemiology and burden of disease Urology. 64 2-6
  • [4] Andersen JT(2011)Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction BJU Int 108 1132-1138
  • [5] Abrams P(2013)Comorbidities and personal burden of urgency urinary incontinence: a systematic review Int J Clin Pract 67 1015-1033
  • [6] Cardozo L(2008)The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study BJU Int 101 1388-1395
  • [7] Fall M(2009)Urinary incontinence is associated with an increase in falls: a systematic review Aust J Physiother 55 89-95
  • [8] Griffiths D(2016)A systematic review of the association between lower urinary tract symptoms and falls, injuries, and fractures in community-dwelling older men Aging Male 19 168-174
  • [9] Rosier P(2015)Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline amendment J Urol 193 1572-1580
  • [10] Ulmsten U(2008)The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis Eur Urol 54 543-562
12345678910