Chemoenzymatic dynamic kinetic resolution of rac-1-phenylethanol in ionic liquids and ionic liquids/supercritical carbon dioxide systems

被引：0
作者：
Pedro Lozano
Teresa De Diego
Mickaël Larnicol
Michel Vaultier
José L. Iborra
机构：
[1] Universidad de Murcia,Departamento de Bioquímica y Biología Molecular B e Inmunología, Facultad de Química
[2] Université de Rennes-1,undefined
[3] Institut de Chimie,undefined
[4] UMR-CNRS 6510,undefined
来源：
Biotechnology Letters | 2006年 / 28卷
关键词：
Dynamic Kinetic Resolution; Ionic liquids; Supercritical fluids; Multiphase biocatalysis; Lipases;
D O I：
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学科分类号：
摘要：
Continuous dynamic kinetic resolution processes in different ionic liquid/supercritical carbon dioxide biphasic systems were carried out by simultaneously using both immobilized Candida antarctica lipase B (Novozym 435) and silica modified with benzenosulfonic acid (SCX) catalysts at 40°C and 10 MPa. SCX was seen to act as an efficient heterogeneous chemical catalyst for the racemization of (S)-1-phenylethanol in different ionic liquid media ([emim][NTf2], [btma][NTf2] and [bmim][PF6]). Coating both chemical and enzymatic catalysts with ILs greatly improved the efficiency of the process, providing a good yield (76%) of (R)-1-phenylethyl propionate product with excellent enantioselectivity (ee = 91–98%) in continuous operation.
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页码：1559 / 1565
页数：6
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