Antibacterial potential of silver nanoparticles against isolated urinary tract infectious bacterial pathogens

被引：24

作者：

Jacob Inbaneson S. ^{[1
]}

Ravikumar S. ^{[1
]}

Manikandan N. ^{[1
]}

机构：

[1] Department of Oceanography and Coastal Area Studies, School of Marine Sciences, Alagappa University, Thondi Campus, Ramanathapuram District, Thondi, 623 409, Tamil Nadu

来源：

Applied Nanoscience | 2011年 / 1卷 / 4期

关键词：

Antibacterial sensitivity; Disc diffusion assay; Silver nanoparticles; UTI;

D O I：

10.1007/s13204-011-0031-2

中图分类号：

学科分类号：

摘要：

The silver nanoparticles were synthesized by chemical reduction method and the nanoparticles were characterized using ultraviolet–visible (UV–Vis) absorption spectroscopy and X-ray diffraction (XRD) studies. The synthesized silver nanoparticles were investigated to evaluate the antibacterial activity against urinary tract infectious (UTIs) bacterial pathogens. Thirty-two bacteria were isolated from mid urine samples of 25 male and 25 female patients from Thondi, Ramanathapuram District, Tamil Nadu, India and identified by conventional methods. Escherichia coli was predominant (47%) followed by Pseudomonas aeruginosa (22%), Klebsiella pneumoniae (19%), Enterobacter sp. (6%), Proteus morganii (3%) and Staphylococcus aureus (3%). The antibacterial activity of silver nanoparticles was evaluated by disc diffusion assay. P. aeruginosa showed maximum sensitivity (11 ± 0.58 mm) followed by Enterobacter sp. (8 ± 0.49 mm) at a concentration of 20 μg disc−1 and the sensitivity was highly comparable with the positive control kanamycin and tetracycline. K. pneumoniae, E. coli, P. morganii and S. aureus showed no sensitivity against all the tested concentrations of silver nanoparticles. The results provided evidence that, the silver nanoparticles might indeed be the potential sources to treat urinary tract infections caused by P. aeruginosa and Enterobacter sp. © 2011, The Author(s).

引用

页码：231 / 236

页数：5

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