Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9

被引：0
作者：
Tomoki Ito
Yui-Hsi Wang
Yong-Jun Liu
机构：
[1] The University of Texas,Department of Immunology and CCIR
[2] M. D. Anderson Cancer Center,undefined
来源：
Springer Seminars in Immunopathology | 2005年 / 26卷
关键词：
Innate immunity; Single-stranded RNA; CpG DNA; MyD88; Anti-viral immunity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Plasmacytoid dendritic cell (pDC) precursors, also called type I IFN (α/β/ω)-producing cells (IPCs), are the key effectors in the innate immune system because of their extraordinary capacity to produce type I IFNs against microbial infection, particularly viral infection. In contrast to myeloid DCs, human pDC/IPCs selectively express Toll-like receptor (TLR) 7 and TLR9 within the endosomal compartment. These receptors are specifically designed to recognize the nucleoside-based products derived from RNA viruses and DNA viruses. Therefore, this expression profile potentially enables pDC/IPCs to sense a variety of viruses. Stimulation of TLR7 or TLR9 leads to type I IFN responses through the MyD88 pathway. Thus, pDC/IPCs may play a central role in host defense against viral infection through the TLR7 and TLR9 system.
引用
收藏
页码：221 / 229
页数：8
相关论文
共 188 条
[1]  
Grouard G(1997)The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand J Exp Med 185 1101-undefined
[2]  
Rissoan MC(1999)The nature of the principal type I interferon-producing cells in human blood Science 284 1835-undefined
[3]  
Filgueira L(2001)Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity Cell 106 259-undefined
[4]  
Siegal FP(2001)Dendritic cell lineage, plasticity and cross-regulation Nat Immunol 2 585-undefined
[5]  
Kadowaki N(1999)Expression of pTα mRNA in a committed dendritic cell precursor in the human thymus Blood 94 2647-undefined
[6]  
Shodell M(2002)Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells Blood 100 3295-undefined
[7]  
Liu YJ(2003)The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development Blood 101 1015-undefined
[8]  
Liu YJ(2000)The function of type I interferons in antimicrobial immunity Curr Opin Immunol 12 419-undefined
[9]  
Kanzler H(2000)Natural interferon α/β-producing cells link innate and adaptive immunity J Exp Med 192 219-undefined
[10]  
Soumelis V(2004)Plasmacytoid dendritic cells regulate Th cell responses through OX40 ligand and type I IFNs J Immunol 172 4253-undefined
12345678910