Infectious complications of biologic therapy in patients with rheumatoid arthritis

被引：8
|
作者：
Meyer-Olson, D. [1 ]
Hoeper, K. [1 ]
Schmidt, R. E. [1 ]
机构：
[1] Hannover Med Sch, Klin Immunol & Rheumatol, Hannover, Germany
来源：
ZEITSCHRIFT FUR RHEUMATOLOGIE | 2010年 / 69卷 / 10期
关键词：
Rheumatoid arthritis; Immunosuppression; Risk of infection; Tuberculosis; Hepatitis B virus infection; Vaccination; MODIFYING ANTIRHEUMATIC DRUGS; HEPATITIS-B; EULAR RECOMMENDATIONS; HERPES-ZOSTER; RISK; VACCINATION; MANAGEMENT; ASSOCIATION; INHIBITORS; DISEASES;
D O I：
10.1007/s00393-010-0677-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The introduction of biological disease-modifying drugs (DMARDs) has substantially improved the treatment options for patients with rheumatoid arthritis. However, infectious complications represent the most common side effects of these drugs, including severe infections as well as rare opportunistic infections. Treating patients on biological DMARDs is therefore one of the biggest challenges in rheumatology care. The present review describes the current state of knowledge regarding frequency and type of infectious complications associated with biological DMARDs. The article focuses mainly on risk management, in particular on diagnosis and recurrence prevention of tuberculosis and reactivation of hepatitis B virus infection. Furthermore, we discuss the importance of vaccinations in primary disease prevention in patients with rheumatoid arthritis.
引用
收藏
页码：879 / 888
页数：10
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