Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes

被引：11
作者：
Yaping Zhao
Chunmei Zhang
Xiaohui Chen
Chunlin Gao
Chenbo Ji
Fukun Chen
Chun Zhu
Jingai Zhu
Jialin Wang
Lingmei Qian
Xirong Guo
机构：
[1] The 82nd Hospital of the People’s Liberation Army,Department of Endocrinology
[2] Nanjing Maternal and Child Health Hospital of Nanjing Medical University,Department of Pediatrics
[3] The First Affiliated Hospital of Nanjing Medical University,Department of Cardiology
来源：
Molecular and Cellular Biochemistry | 2010年 / 340卷
关键词：
Adipocyte; Insulin resistance; Mitochondria;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
NYGGF4 is a recently discovered gene that is involved in obesity-associated insulin resistance. The exact mechanism by which NYGGF4 induces insulin resistance has not yet been fully elucidated. In this study, we demonstrated that the overexpression of NYGGF4 in 3T3-L1 adipocytes decreased mitochondrial mass, mitochondrial DNA, and intracellular ATP synthesis. In addition, NYGGF4 overexpression also led to an imbalance of the mitochondrial dynamics and excess intracellular ROS production. Collectively, our results indicated that the overexpression of NYGGF4 caused mitochondrial dysfunction in adipocytes, which might be responsible for the development of NYGGF4-induced insulin resistance.
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页码：41 / 48
页数：7
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