Management of Chronic Lymphocytic Leukaemia

被引：0
作者：
Nelson Kalil
Bruce D. Cheson
机构：
[1] National Cancer Institute,
来源：
Drugs & Aging | 2000年 / 16卷
关键词：
Chronic Lymphocytic Leukaemia; Fludarabine; Chlorambucil; Cladribine; Chronic Lymphocytic Leukaemia Cell;
D O I：
暂无
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学科分类号：
摘要：
Chronic lymphocytic leukaemia (CLL) is the most common form of adult leukaemia in Western countries. The diagnosis requires mature-appearing lymphocytes in the peripheral blood to >5 × 109/L. The immunophenotype typically includes B cell antigens CD19, CD20 and CD23, low expression of surface immunoglobulin and CD5+, with other T cell antigens absent. Bone marrow biopsy, although not required for diagnosis, must show at least 30% lymphocytes. Cytogenetic abnormalities are frequent in patients with CLL, and may be associated with poor prognosis.
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页码：9 / 27
页数：18
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[1]  
Landis SH(1998)Cancer statistics CA Cancer J Clin 48 6-29
[2]  
Murray T(1988)Guidelines for clinical protocols for chronic lymphocytic leukemia: report of the NCI-sponsored Working Group Am J Hematol 29 152-63
[3]  
Bolden S(1996)National Cancer Institute-Sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment Blood 87 4990-7
[4]  
Cheson BD(1994)A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group Blood 84 1361-92
[5]  
Bennett JM(1989)Proposals for the classification of chronic (mature) B and T lymphoid leukaemias J Clin Pathol 42 567-84
[6]  
Rai KR(1985)Defective complement activity in chronic lymphocytic leukemia Am J Hematol 19 63-73
[7]  
Cheson BD(1998)The infectious complications of chronic lymphocytic leukemia Semin Oncol 25 98-106
[8]  
Bennett JM(1993)Richter’s syndrome: a report on 39 patients J Clin Oncol 11 1985-9
[9]  
Grever M(1986)The relationship between chronic lymphocytic leukaemia and prolymphocytic leukaemia III: evaluation of cell size by morphology and volume measurements Br J Haematol 64 469-78
[10]  
Harris NL(1986)The relationship between chronic lymphocytic leukaemia and prolymphocytic leukaemia: I. Clinical and laboratory features of 300 patients and characterization of an intermediate group Br J Haematol 63 377-87
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