Antifungal effects of new heterocyclic compounds, 6H-pyrimido[2,1-a]isoindole derivatives

被引：0

作者：

K. Nesměrák

H. Pelouchová

V. Všetečka

I. Němec

J. Gabriel

机构：

[1] Charles University,Faculty of Science

[2] Academy of Sciences of the Czech Republic,Institute of Microbiology

来源：

Folia Microbiologica | 1998年 / 43卷

关键词：

Lactis; Ergot Alkaloid; Cyclopiazonic Acid; Linear Assembly; Isoindole;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Minimal inhibitory concentrations for 10 new condensed isoindole derivatives were established by the agar diffusion method. Benzo[b]-6H-pyrimido[2,1-a]isoindole-4-one exhibited a broad antifungal effect; the observed MIC (mg/L) were 7 (K. lactis), 8 (C. pseudotropicalis), 17 (W. fluorescens), 22 (E. magnusii), 31 (P. membranaefaciens), 32 (S. alluvius) and 32 (S. cerevisiae). The compound also inhibited the growth ofB. subtilis (MIC 9 mg/L). No effect on the growth ofE. coli was found.

引用

页码：39 / 41

页数：2

共 3 条

[1] Synthesis and Spectral Characterization of Benzo-[6,7][1,5] diazocino[2,1-a]isoindol-12-(14H)-one Derivatives
Bassin, Jatinder P.
Anagani, Bhavani
Benham, Christopher
Goyal, Madhu
Hashemian, Maryam
Gerhard, Ute
MOLECULES, 2016, 21 (08):
[2] Regioselective Synthesis of 5H-Benzo[4,5]imidazo[2,1-a]isoindole Linked 1,2,3-Traizole Hybrids and Their Anti-Proliferative Activity
M. Srinivas Reddy
T. Narasimha Swamy
M. Ravinder
Satheesh Kumar Nukala
Russian Journal of General Chemistry, 2021, 91 : 1135 - 1139
[3] Regioselective Synthesis of 5H-Benzo[4,5]imidazo[2,1-a]isoindole Linked 1,2,3-Traizole Hybrids and Their Anti-Proliferative Activity
Reddy, M. Srinivas
Swamy, T. Narasimha
Ravinder, M.
Nukala, Satheesh Kumar
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2021, 91 (06) : 1135 - 1139

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