Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice

被引：0
作者：
Paxton M. Moon
Frank Beier
机构：
[1] Western University,Department of Physiology and Pharmacology
[2] Children’s Health Research Institute,undefined
来源：
Current Rheumatology Reports | 2015年 / 17卷
关键词：
Osteoarthritis; Cartilage; Mouse; Bone; Synovium; Joint; KO; DMM;
D O I：
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中图分类号：
学科分类号：
摘要：
Osteoarthritis causes tremendous individual suffering and staggering societal costs, but due to our limited understanding of the underlying molecular and cellular mechanisms, our avenues for treating this disease are very restricted. Recent years have seen a drastic increase in the use of genetically modified mice to characterize the pathophysiology of osteoarthritis. Many new players and mechanisms driving osteoarthritis pathogenesis have been elucidated, some of which might be strong candidates as therapeutic targets for the human disease. The current review summarizes key findings (selected subjectively by the authors) from mouse osteoarthritis studies over recent years.
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