Autogenous bone marrow concurrent with static magnetic field effects on bone-defect healing: Radiological and histological study

被引:8
作者
Bigham A.S. [1 ]
Shadkhast M. [2 ]
Dehghani S.N. [3 ]
机构
[1] Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord
[2] Department of Veterinary Anatomical and Histological Science, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord
[3] Department of Surgery, School of Veterinary Medicine, Shiraz University, Shiraz
关键词
Bone healing; Bone marrow; Rabbit; Static magnetic field;
D O I
10.1007/s00580-008-0777-4
中图分类号
学科分类号
摘要
To stimulate the process of bone healing, several methods have been used previously. These methods include use of ultrasound, electrical stimulation, exposure to electromagnetic field, bone graft, interporous hydroxyapatite (as a bone graft substitute). The aim of this study was evaluation of bone-defect healing with autogenous bone marrow concurrent with static magnetic field. Twenty adolescents, 2-kg-weighing, white New Zealand male rabbits were used in this study. In the control group (n = 10) mid-radii bone defect was created and filled with harvested bone marrow. In the experimental group (n = 10) the procedure was similar to control group with static magnetic application over the bone-defect area. Radiological, histopathological and evaluations were performed blindly and results scored and analyzed statistically. The results show those experimental groups were superior to control group in radiological and histological evaluation. © Springer-Verlag London Limited 2008.
引用
收藏
页码:163 / 168
页数:5
相关论文
共 25 条
[1]  
An Y.H., Friedman R.J., Animal Models in Orthopedic Research, pp. 204-205, (1999)
[2]  
Beresford J.N., Osteogenic stem cells and the stromal system of bone and marrow, Clin Orthop Relat Res, 240, pp. 270-280, (1989)
[3]  
Berggren A., Weiland A.L., Ostrup L.T., Dorfinan H., The effects of storage media and perfusion on osteoblast and osteocyte survival in free composite bone grafts, J Microsurg, 2, pp. 273-282, (1981)
[4]  
Bolander M.E., Galian G., The use of demineralize bone matrix in the repair of segmental defect, J Bone J Surg, 68 A, pp. 1264-1274, (1983)
[5]  
Bruce G.K., Howlett C.R., Huckstep R.L., Effect of a static magnetic field on fracture healing in a rabbit radius: Preliminary results, Clin Orthop Relat Res, 222, pp. 300-306, (1987)
[6]  
Caplan A.I., Bruder S.P., Cell and molecular engineering of bone regeneration, Principles of Tissue Engineering, pp. 603-619, (1997)
[7]  
Chiu K.H., Ou K.L., Lee S.Y., Lin C.T., Chang W.J., Chen C.C., Et al., Static magnetic fields promote osteoblast-like cells differentiation via increasing the membrane rigidity, Ann Biomed Eng, 35, pp. 1932-1939, (2007)
[8]  
Connolly J., Guse R., Lippirllo L., Dehne R., Development of an osteogenic bone marrow preparation, J Bone Joint Surg Am, 71, pp. 684-691, (1989)
[9]  
Cummin J., Nade S., Osteogenesis after bone and bone marrow transplantation, Acta Orthop Scand, 48, pp. 15-24, (1997)
[10]  
Damien C.J., Parsons J.R., Bone graft and bone graft substitutes: A review of current technology and applications, J Appl Biomater, 2, pp. 187-208, (1991)