Gold nanorod stabilized by thiolated chitosan as photothermal absorber for cancer cell treatment

被引：0
作者：
Chung-Hao Wang
Chia-Wei Chang
Ching-An Peng
机构：
[1] National Taiwan University,Department of Chemical Engineering
[2] Michigan Technological University,Department of Chemical Engineering
来源：
Journal of Nanoparticle Research | 2011年 / 13卷
关键词：
Gold nanorods; Photothermolysis; NIR laser; Thiolated chitosan; Folic acid; Nanomedicine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Gold nanorod (GNR) has great potential in the field of cancer therapy because of its photophysical property in converting near-infrared (NIR) laser light into heat. Fabrication of GNRs by seed-mediated growth method with the aid of cetyltrimethylammonium bromide (CTAB) is a popular approach. However, due to high cytotoxicity of CTAB, it is necessary to modify the surface of CTAB-passivated GNRs for cell-related studies. In this study, thiolated chitosan was synthesized and harnessed to replace CTAB originally used to stabilize GNRs. The average size and morphological shape of CTAB-passivated GNRs (66.0 nm) and thiolated chitosan-modified GNRs (CGNRs) (84.9 nm) were determined by dynamic light scattering and transmission electron microscopy. X-ray photoelectron spectroscopy was used to confirm the existence of Au–S binding energy at 162.4 eV. Cytotoxicity study revealed that CGNRs were much biocompatible than CTAB-stabilized GNRs. Our results showed that CGNRs functionalized with folic acid (FA) could be internalized by human colon HT-29 cancer cells via folate-mediated endocytosis. From the viability of CGNR-laden HT-29 cells irradiated with 808-nm NIR laser light, we demonstrated that CGNR is a potential photothermal nano-absorber for the ablation of malignant cells under NIR laser exposure.
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页码：2749 / 2758
页数：9
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