Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial

被引：0

作者：

M. M. Koeneman

A. J. Kruse

L. F. S. Kooreman

A. zur Hausen

A. H. N. Hopman

S. J. S. Sep

T. Van Gorp

B. F. M. Slangen

H. J. van Beekhuizen

A. J. M. van de Sande

C. G. Gerestein

H. W. Nijman

R. F. P. M. Kruitwagen

机构：

[1] Maastricht University Medical Center,Department of Obstetrics and Gynaecology

[2] Maastricht University Medical Center,GROW, School for Oncology and Developmental Biology

[3] Maastricht University Medical Center,Department of Pathology

[4] Maastricht University Medical Center,Department of Molecular Cell Biology

[5] Maastricht University Medical Center,Department of Internal Medicine

[6] Department of Obstetrics and Gynaecology,Department of Obstetrics and Gynaecology

[7] Erasmus MC Cancer Institute,undefined

[8] Department of Obstetrics and Gynaecology,undefined

[9] Meander Medical Center,undefined

[10] University Medical Center Groningen,undefined

来源：

BMC Cancer | / 17卷

关键词：

Cervical intraepithelial neoplasia; Imiquimod; Biological markers; Human papillomavirus; Natural history;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The “TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia” (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5% cream in high-grade cervical intraepithelial neoplasia (CIN). The lagging inclusions were mainly due to a strong patient preference for either of the two treatment modalities. This prompted us to initiate a new study on the same subject, with a non-randomized, open-label design: the ‘TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC)-3’ study.

引用

共 13 条

[1]

Koeneman MM(2016)TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): study protocol for a randomized controlled trial BMC Cancer 16 132-undefined

[2]

Kruse AJ(undefined)undefined undefined undefined undefined-undefined

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Kooreman LF(undefined)undefined undefined undefined undefined-undefined

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Zur Hausen A(undefined)undefined undefined undefined undefined-undefined

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Hopman AH(undefined)undefined undefined undefined undefined-undefined

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Sep SJ(undefined)undefined undefined undefined undefined-undefined

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Van Gorp T(undefined)undefined undefined undefined undefined-undefined

[8]

Slangen BF(undefined)undefined undefined undefined undefined-undefined

[9]

van Beekhuizen HJ(undefined)undefined undefined undefined undefined-undefined

[10]

van de Sande M(undefined)undefined undefined undefined undefined-undefined

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