Recommendations for the treatment of epilepsy in adult patients in general practice in Belgium: an update

被引:0
作者
Paul Boon
Sebastiaan Engelborghs
Henri Hauman
An Jansen
Lieven Lagae
Benjamin Legros
Michel Ossemann
Bernard Sadzot
Katrien Smets
Etienne Urbain
Kenou van Rijckevorsel
机构
[1] Ghent University Hospital,Department of Neurology
[2] Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken,Department of Neurology and Memory Clinic
[3] Institute Born-Bunge,Department of Neurology
[4] University of Antwerp,Department of Paediatric Neurology
[5] Sint-Maarten Hospital,Department of Paediatric Neurology
[6] University Hospital Brussels,Department of Neurology
[7] Free University Brussels,Department of Neurology
[8] University Hospital,Department of Neurology
[9] Hôpital Erasme,Department of Neurology
[10] Université Libre de Bruxelles,Department of Neurology
[11] University Hospital Mont-Godinne,Department of Paediatric Neurology
[12] Université Catholique de Louvain,undefined
[13] University Hospital Centre Sart-Tilman,undefined
[14] Antwerp University Hospital,undefined
[15] University of Antwerp,undefined
[16] Grand Hôpital de Charleroi,undefined
[17] Saint Luc University Hospital,undefined
[18] Université Catholique de Louvain,undefined
来源
Acta Neurologica Belgica | 2012年 / 112卷
关键词
Epilepsy; Antiepileptic drugs; Seizures; Treatment; Recommendations;
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摘要
In 2008, a group of Belgian epilepsy experts published recommendations for antiepileptic drug (AED) treatment of epilepsies in adults and children. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence for efficacy, common daily practice and the personal views and experiences of the authors. In November 2011 the validity of these recommendations was reviewed by the same group of Belgian epilepsy experts who contributed to the preparation of the original paper. The recommendations made in 2008 for initial monotherapy in paediatric patients were still considered to be valid, except for the first choice treatment for childhood absence epilepsy. This update therefore focuses on the treatment recommendations for initial monotherapy and add-on treatment in adult patients. Several other relevant aspects of treatment with AEDs are addressed, including considerations for optimal combination of AEDs (rational polytherapy), pharmacokinetic properties, pharmacodynamic and pharmacokinetic interaction profile, adverse effects, comorbidity, treatment of elderly patients, AED treatment during pregnancy, and generic substitution of AEDs.
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页码:119 / 131
页数:12
相关论文
共 195 条
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