The Ambivalent Role of lncRNA Xist in Carcinogenesis

被引：0
作者：
Yung-Kang Chen
Yun Yen
机构：
[1] Taipei Medical University,School of Medicine
[2] Taipei Veterans General Hospital,Department of General Medicine
[3] Taipei Medical University,Graduate Institute of Medical Informatics
[4] Taipei Medical University,TMU Research Center of Cancer Translational Medicine
[5] Taipei Medical University,Taipei Municipal Wanfang Hospital
[6] Taipei Medical University,Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology
来源：
Stem Cell Reviews and Reports | 2019年 / 15卷
关键词：
Cancer stem cell; Long non-coding RNA; X Chromosome inactivation; XIST non-coding RNA; XACT non-coding RNA; MicroRNAs; Competing endogenous RNA; Exosomes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. In this review, we discuss recent advances of XCI in human embryonic stem cells and provide an explanation for the seemingly contradictory roles of Xist in development of human cancer.
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页码：314 / 323
页数：9
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