Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

被引：0
作者：
Tao Long
Michael Hicks
Hung-Chun Yu
William H Biggs
Ewen F Kirkness
Cristina Menni
Jonas Zierer
Kerrin S Small
Massimo Mangino
Helen Messier
Suzanne Brewerton
Yaron Turpaz
Brad A Perkins
Anne M Evans
Luke A D Miller
Lining Guo
C Thomas Caskey
Nicholas J Schork
Chad Garner
Tim D Spector
J Craig Venter
Amalio Telenti
机构：
[1] Human Longevity,Department of Twin Research and Genetic Epidemiology
[2] Inc.,undefined
[3] San Diego,undefined
[4] California,undefined
[5] USA,undefined
[6] King's College,undefined
[7] Health Nucleus,undefined
[8] Human Longevity Singapore,undefined
[9] Pte. Ltd.,undefined
[10] Metabolon,undefined
[11] Inc.,undefined
[12] Molecular and Human Genetics,undefined
[13] Baylor College of Medicine,undefined
[14] J. Craig Venter Institute,undefined
[15] Present address: Sanford Burnham Prebys Medical Discovery Institute,undefined
[16] La Jolla,undefined
[17] California,undefined
[18] USA.,undefined
来源：
Nature Genetics | 2017年 / 49卷
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学科分类号：
摘要：
Amalio Telenti, Craig Venter and colleagues report common, low-frequency and rare variants associated with blood metabolite levels using whole-genome sequencing and comprehensive metabolite profiling in 1,960 individuals. They identify 246 metabolites whose levels are associated with genetic variation at 101 loci.
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页码：568 / 578
页数：10
相关论文
共 101 条
  • [1] Yousri NA(2014)Long term conservation of human metabolic phenotypes and link to heritability Metabolomics 10 1005-1017
  • [2] Suhre K(2012)Genetic variation in metabolic phenotypes: study designs and applications Nat. Rev. Genet. 13 759-769
  • [3] Gieger C(2015)Genetics of human metabolism: an update Hum. Mol. Genet. 24 R93-R101
  • [4] Kastenmüller G(2011)A genome-wide association study of metabolic traits in human urine Nat. Genet. 43 565-569
  • [5] Raffler J(2014)An atlas of genetic influences on human blood metabolites Nat. Genet. 46 543-550
  • [6] Gieger C(2015)Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels Nat. Commun. 6 7208-E4910
  • [7] Suhre K(2016)Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA Nat. Commun. 7 11122-355
  • [8] Suhre K(2015)Plasma metabolomic profiles enhance precision medicine for volunteers of normal health Proc. Natl. Acad. Sci. USA 112 E4901-491
  • [9] Shin SY(2015)Association of rare loss-of-function alleles in Circ Cardiovasc Genet 8 351-149
  • [10] Draisma HH(2016), serum histidine: levels and incident coronary heart disease Genet. Epidemiol. 40 486-85
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