5',6',7',8'-Tetrahydro-1'H,3'H-spiro[cyclohexane-1,2'-quinazolin]-4'-one in Mannich reaction

被引:0
作者
V. I. Markov
O. K. Farat
机构
[1] Ukrainian State Chemical and Technological University,
来源
Chemistry of Heterocyclic Compounds | 2012年 / 48卷
关键词
alkaloids; 3-azabicyclo[3.3.1]nonane; cage amines; quinazolin-4(3; )-ones; Mannich reaction;
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学科分类号
摘要
The Mannich aminomethylation of 5',6',7,'8'-tetrahydro-1'H,3'H-spiro[cyclohexane-1,2'-quinazolin]-4'-one leads to formation of a heterocyclic system containing an annelated azabicyclic fragment. Hydrolysis of the indicated spirans gives 3-azabicyclo[3.3.1]nonanes.
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页码:925 / 930
页数:5
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