Preparation and characterization of novel antibacterial blended films based on modified carboxymethyl cellulose/phenolic compounds

被引:0
作者
Engy M. Akl
Sawsan Dacrory
Mohamed S. Abdel-Aziz
Samir Kamel
Asmaa M. Fahim
机构
[1] National Research Centre,Department of Fats and Oils
[2] National Research Centre,Department of Cellulose and Paper
[3] National Research Centre,Department of Microbial Chemistry
[4] National Research Centre,Department of Green Chemistry
来源
Polymer Bulletin | 2021年 / 78卷
关键词
Agriculture waste; Blended films; Antimicrobial activity; Molecular docking; Quantum chemical calculations;
D O I
暂无
中图分类号
学科分类号
摘要
The objective of this work is to re-use of agriculture waste via an environmentally friendly procedure to introduce multifunctional cellulose-based blend films using sesame seed meal extracted from agriculture wastes. The current strategy demonstrated the identification and evaluation of the bioactive compounds of sesame seed meal extracted from agricultural wastes via an ultrasonic procedure. Then, the sesame seed meal extract was loaded onto modified carboxymethyl cellulose within a matrix of a blend film. A cross-linked blend films based on the biocompatible modified carboxymethyl cellulose (m-CMC) with phenolic compounds (Ph) extracted from sesame seed meal were developed. The cross-linked m-CMC/Ph films were investigated by Fourier transform infrared spectroscopic analysis, while the surface morphology was investigated using scanning electron microscopy. Both mechanical and swelling properties were investigated. The m-CMC/Ph film exhibited excellent antioxidant performance as well as antibacterial activity against Staphylococcus aureus as Gram-positive pathogenic bacteria and Pseudomonas aeruginosa as Gram-negative pathogenic bacteria using colony-forming unit to provide further biocompatibility for prepared blend films. Additionally, molecular docking studies were carried out on effective films to evaluate their potential interaction against P. aeruginosa LolA (PDB: 2W7Q) and S. aureus metalloproteinase (PDB:1BQB) with a binding energy of − 3.7 kcal/mol and − 2.8 kcal/mol and short bond length of 2.076 Å and 1.144 Å, respectively. The computational calculations of the optimized monomer CMC and gallic acid were carried out to elucidate the HOMO–LUMO energy gap and interaction between them as well as the optimization of m-CMC/Ph to evaluate their interaction and film stability. As a result, the present study presents a novel simple approach to design smart biocompatible films for multifunctional healthcare and medical purposes using the biologically active extracts from sustainable plant wastes.
引用
收藏
页码:1061 / 1085
页数:24
相关论文
共 50 条
[31]   Preparation and characterization of novel antibacterial castor oil-based polyurethane membranes for wound dressing application [J].
Yari, Abbas ;
Yeganeh, Hamid ;
Bakhshi, Hadi ;
Gharibi, Reza .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, 102 (01) :84-96
[32]   Preparation, characterization and long-term antibacterial activity of nisin anchored magnetic cellulose beads [J].
Wu, Hao ;
Tian, HuaFeng ;
Li, ShuJing ;
Wang, YuTang ;
Ma, ZhaoCheng ;
Song, ZiHan ;
Wang, JianGuo .
CELLULOSE, 2020, 27 (01) :357-367
[33]   Preparation and Characterization of Chitosan/Poly(Vinyl Alcohol) Blended Films: Mechanical, Thermal and Surface Investigations [J].
El-Hefian, Esam A. ;
Nasef, Mohamed Mahmoud ;
Yahaya, Abdul Hamid .
E-JOURNAL OF CHEMISTRY, 2011, 8 (01) :91-96
[34]   Preparation and Characterization of Chitosan/Agar Blended Films: Part 1. Chemical Structure and Morphology [J].
El-Hefian, Esam. A. ;
Nasef, Mohamed Mahmoud ;
Yahaya, Abdul Hamid .
E-JOURNAL OF CHEMISTRY, 2012, 9 (03) :1431-1439
[35]   Preparation, Characterization and Application of the Novel Chitosan Derivative Modified with Phenylalanine [J].
Sang, Wei ;
Tang, Zhe ;
He, Ming-Yang ;
Hua, Yong-Pei ;
Xu, Qi .
FIBERS AND POLYMERS, 2015, 16 (05) :991-996
[36]   Preparation, characterization and application of the novel chitosan derivative modified with phenylalanine [J].
Wei Sang ;
Zhe Tang ;
Ming-Yang He ;
Yong-Pei Hua ;
Qi Xu .
Fibers and Polymers, 2015, 16 :991-996
[37]   Preparation, characterization and antibacterial properties of 6-deoxy-6-arginine modified chitosan [J].
Su, Zhiwei ;
Han, Qiming ;
Zhang, Fang ;
Meng, Xianghong ;
Liu, Bingjie .
CARBOHYDRATE POLYMERS, 2020, 230
[38]   Ultrasound-Assisted Preparation, Characterization, and Antibacterial Activity of Montmorillonite Modified by ε-Polylysine Hydrochloride [J].
Yuan, Xinfu ;
Zhang, Jinli ;
Zhang, Rui ;
Liu, Jingyuan ;
Wang, Wentao ;
Hou, Hanxue .
MATERIALS, 2019, 12 (24)
[39]   Preparation of green cellulose diacetate-based antibacterial wound dressings for wound healing [J].
Xiao, Chuang ;
Zhang, Ge ;
Liang, Wencheng ;
Wang, Zhaochuang ;
Lu, Qiaohui ;
Shi, Weibin ;
Zhou, Yan ;
Guan, Yong ;
Lang, Meidong .
FRONTIERS OF MATERIALS SCIENCE, 2022, 16 (02)
[40]   Preparation and Characterization of Cellulose Acetate/Corn Silk Extract Films for Potential Antimicrobial Application [J].
Hassanein, Heba D. ;
Tohamy, Hebat-Allah S. ;
AbdelMohsen, Mona M. ;
El-Masry, Hossam M. ;
El-Sakhawy, Mohamed .
EGYPTIAN JOURNAL OF CHEMISTRY, 2024, 68 (01) :287-294