Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: A retrospective cohort study

被引：5
作者：
Mortensen E.M. [1 ,2 ]
Restrepo M.I. [1 ,3 ]
Pugh J.A. [1 ,2 ]
Anzueto A. [1 ,3 ]
机构：
[1] VERDICT Research Program, Audie L Murphy VA Hospital, San Antonio, TX 78229
[2] Divisions of General Medicine/Hospital Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229
[3] Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229
来源：
BMC Research Notes | / 1卷 / 1期
关键词：
Pneumonia; Intensive Care Unit Admission; Streptococcus Pneumoniae; Pneumonia Severity Index; Protected Specimen Brush;
D O I：
10.1186/1756-0500-1-120
中图分类号：
学科分类号：
摘要：
Background. The purpose of this study was to examine whether prior outpatient antibiotic use is associated with increased 30-day mortality, after adjusting for potential confounders, for those subsequently hospitalized with pneumonia. Methods. A retrospective cohort study conducted at two tertiary teaching hospitals. Eligible subjects were admitted with a diagnosis of, and had a chest x-ray consistent with, community-acquired pneumonia. Our primary analysis was a multivariable logistic regression with the dependent variable of 30-day mortality. Results. Data was abstracted on 733 subjects at the two hospitals. Mortality was 8.1% at 30-days. At presentation, 55% of subjects were low risk, 33% were moderate risk, and 12% were high risk. In our cohort 17% (n = 128) of subjects received antibiotics within 30-days of presentation. Unadjusted mortality for those who had received prior antibiotics was 7.0% vs. 8.3% for those who had not (p = 0.6). In the multivariable analysis prior use of antibiotics (odds ratio 0.98, 95% confidence interval 0.5-2.1) was not significantly associated with 30-day mortality. Conclusion. Receipt of prior outpatient antibiotics is not significantly associated with 30-day mortality for patients hospitalized with pneumonia. Our study supports current efforts to increase the number of patients with pneumonia who are treated as outpatients. © 2008 Mortensen et al; licensee BioMed Central Ltd.
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