Targeting Translation of mRNA as a Therapeutic Strategy in Cancer

[1] Haghighat A(1995)Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E EMBO J 14 5701-5709

[2] Mader S(1999)Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism Genes Dev 13 1422-1437

[3] Pause A(1997)Regulation of eIF-4E BP1 phosphorylation by mTOR J Biol Chem 272 26457-26463

[4] Sonenberg N(2002)Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E Genes Dev 16 1472-1487

[5] Gingras AC(2014)Casein kinase 1epsilon promotes cell proliferation by regulating mRNA translation Cancer Res 74 201-211

[6] Gygi SP(2017)Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kdelta and CK1epsilon in hematological malignancies Blood 129 88-99

[7] Raught B(2012)Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding Nucleic Acids Res 40 6353-6366

[8] Polakiewicz RD(2009)MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy Blood 114 3533-3537

[9] Abraham RT(2010)Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab J Clin Oncol 28 3360-3365

[10] Hoekstra MF(2012)Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone J Clin Oncol 30 3452-3459

[1] Haghighat A(1995)Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E EMBO J 14 5701-5709

[2] Mader S(1999)Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism Genes Dev 13 1422-1437

[3] Pause A(1997)Regulation of eIF-4E BP1 phosphorylation by mTOR J Biol Chem 272 26457-26463

[4] Sonenberg N(2002)Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E Genes Dev 16 1472-1487

[5] Gingras AC(2014)Casein kinase 1epsilon promotes cell proliferation by regulating mRNA translation Cancer Res 74 201-211

[6] Gygi SP(2017)Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kdelta and CK1epsilon in hematological malignancies Blood 129 88-99

[7] Raught B(2012)Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding Nucleic Acids Res 40 6353-6366

[8] Polakiewicz RD(2009)MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy Blood 114 3533-3537

[9] Abraham RT(2010)Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab J Clin Oncol 28 3360-3365

[10] Hoekstra MF(2012)Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone J Clin Oncol 30 3452-3459