Experimental and simulation studies on the behavior of signal harmonics in magnetic particle imaging

被引：14

作者：

Murase K. ^{[1
]}

Konishi T. ^{[1
]}

Takeuchi Y. ^{[1
]}

Takata H. ^{[1
]}

Saito S. ^{[1
]}

机构：

[1] Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Osaka 565-0871

来源：

Radiological Physics and Technology | 2013年 / 6卷 / 2期

基金：

日本学术振兴会;

关键词：

Drive magnetic field; Magnetic nanoparticles; Magnetic particle imaging; Selection magnetic field; Signal harmonics;

D O I：

10.1007/s12194-013-0213-6

中图分类号：

学科分类号：

摘要：

Our purpose in this study was to investigate the behavior of signal harmonics in magnetic particle imaging (MPI) by experimental and simulation studies. In the experimental studies, we made an apparatus for MPI in which both a drive magnetic field (DMF) and a selection magnetic field (SMF) were generated with a Maxwell coil pair. The MPI signals from magnetic nanoparticles (MNPs) were detected with a solenoid coil. The odd- and even-numbered harmonics were calculated by Fourier transformation with or without background subtraction. The particle size of the MNPs was measured by transmission electron microscopy (TEM), dynamic light-scattering, and X-ray diffraction methods. In the simulation studies, the magnetization and particle size distribution of MNPs were assumed to obey the Langevin theory of paramagnetism and a log-normal distribution, respectively. The odd- and even-numbered harmonics were calculated by Fourier transformation under various conditions of DMF and SMF and for three different particle sizes. The behavior of the harmonics largely depended on the size of the MNPs. When we used the particle size obtained from the TEM image, the simulation results were most similar to the experimental results. The similarity between the experimental and simulation results for the even-numbered harmonics was better than that for the odd-numbered harmonics. This was considered to be due to the fact that the odd-numbered harmonics were more sensitive to background subtraction than were the even-numbered harmonics. This study will be useful for a better understanding, optimization, and development of MPI and for designing MNPs appropriate for MPI. © 2013 Japanese Society of Radiological Technology and Japan Society of Medical Physics.

引用

页码：399 / 414

页数：15

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