Search for new drugs: Synthesis and tuberculostatic activity of some substituted amino acid methyl esters with sym-tetrazine moieties

被引：0

作者：

Rusinov G.L. ^{[1
]}

Latosh N.I. ^{[1
]}

Ishmetova R.I. ^{[1
]}

Kravchenko M.A. ^{[2
]}

Ganebnykh I.N. ^{[1
]}

Sokolov V.A. ^{[2
]}

Chupakhin O.N. ^{[1
]}

机构：

[1] Institute of Organic Synthesis, Ural Division, Russian Academy of Sciences, Yekaterinburg

[2] Ural Research Institute of Phthisiopulmonology, Yekaterinburg

来源：

Pharmaceutical Chemistry Journal | 2005年 / 39卷 / 1期

基金：

俄罗斯基础研究基金会;

关键词：

Methyl; Ester; Organic Chemistry; Methyl Ester; Acid Methyl Ester;

D O I：

10.1007/s11094-005-0068-1

中图分类号：

学科分类号：

摘要：

The products of nucleophilic substitution of methyl esters of seven amino acids for the 3,5-dimethylpyrazolyl moiety in 3,6-bis(3,5-dimethylpyrazol-l-yl)- 5-tetrazine were obtained. One of these compounds exhibited tuberculocidal action at a concentration of 0.6 μg/ml. In contrast, two other compounds stimulated the growth of mycobacterium colonies. © 2005 Springer Science+Business Media, Inc.

引用

页码：8 / 10

页数：2

共 8 条

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