Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis

被引:0
作者
P. R. Usha
M. U. R. Naidu
机构
[1] Nizam’s Institute of Medical Sciences,Department of Clinical Pharmacology and Therapeutics
来源
Clinical Drug Investigation | 2004年 / 24卷
关键词
Osteoarthritis; Chondroitin Sulfate; Efficacy Parameter; Diary Card; Case Record Form;
D O I
暂无
中图分类号
学科分类号
摘要
Objective: Glucosamine, classified as a slow-acting drug in osteoarthritis (SADOA), is an efficacious chondroprotective agent. Methylsulfonylmethane (MSM), the isoxidised form of dimethyl-sulfoxide (DSMO), is an effective natural analgesic and anti-inflammatory agent. The aim of this study was to compare the efficacy and safety of oral glucosamine (Glu), methylsulfonylmethane (MSM), their combination and placebo in osteoarthritis of the knee.
引用
收藏
页码:353 / 363
页数:10
相关论文
共 96 条
  • [11] Jimenez R.A.H.(1967)Local application of dimethyl sulfoxide, DMSO combined with triamcinolone acetonide in rheumatoid arthritis Ann N Y Acad sci 141 555-90
  • [12] Willkens R.F.(1986)FDA Advisory Committee meeting: methotrexate; guidelines for the clinical evaluation of anti-inflammatory drugs; DMSO in scleroderma Arthritis Rheum 29 1289-9
  • [13] Murav’ev Iu V.(1984)Use of dimethyl sulfoxide for treating flexion contractures in rheumatoid arthritis patients Ter Arkh 56 128-4
  • [14] Venikova M.S.(1994)Protective effect of doxorubicin in vitamin C or dimethyl sulfoxide against skin ulceration in the pig Ann Surg Oncol 1 411-5
  • [15] Pleskovskaia G.N.(1987)Local application of pentacin in dimethyl sufoxide in skin burns contaminated with 241AM Vestn Dermatol Venerol 1 53-54
  • [16] Riazantseva T.A.(1998)Intermittent use of topical dimethyl sulfoxide in macular and popular amyloidosis Int J Dermatol 37 949-6
  • [17] Sigidin Ia A.(1995)Calcium, sulfur and zinc distribution in normal and arthritic articular equine cartilage: a synchroton radiation-induced X-ray emission (SRIXE) study J Exp Zool 273 82-6
  • [18] Jacob S.W.(1982)Indexes of severity for osteo-arthritis of the hip and knee: validation-value in comparison with other assessment tests Scand J Rheumatol 22 2290-501
  • [19] Herschler R.(1957)Radiological assessment of osteoarthrosis Ann Rheum Dis 16 494-9
  • [20] Fox R.B.(1996)Pain measurement tools for clinical practice and research J Am Assoc Nurse Anesth 64 133-8