Galactomannan detection in bronchoalveolar lavage fluid

被引：0
作者：
Eun Jeong Kwak
M. Hong Nguyen
机构：
[1] University of Pittsburgh Medical Center,Division of Infectious Disease, Department of Medicine
来源：
Current Fungal Infection Reports | 2008年 / 2卷 / 4期
关键词：
Aspergillosis; Invasive Aspergillosis; Galactomannan; Invasive Pulmonary Aspergillosis; Lung Transplant Recipient;
D O I：
10.1007/s12281-008-0030-2
中图分类号：
学科分类号：
摘要：
Prompt diagnosis of invasive pulmonary aspergillosis (IPA) remains a challenge. Galactomannan (GM) assay in serum has been incorporated into diagnostic criteria for IPA, but its performance varies depending on the population in which the test is used. GM assay on bronchoalveolar lavage (BAL) fluid aims to improve upon the test by applying it directly on samples from the target organ. The studies that have examined the utility of BAL-GM are a heterogeneous group, but the results are intriguing, especially in patients who are at risk for IPA from causes other than hematologic malignancy and neutropenia. BAL-GM had sensitivities ranging from 60% to 100% in this group, often far exceeding the performance of serum GM assay. The test shows promise as a useful adjunctive diagnostic modality in the diagnosis of IPA.
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页码：206 / 213
页数：7
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