The Emerging Role of Astrocytic Autophagy in Central Nervous System Disorders

被引：0
作者：
Zhuchen Zhou
Jing Zhou
Jie Liao
Zhong Chen
Yanrong Zheng
机构：
[1] Zhejiang Chinese Medical University,Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences
[2] Zhejiang University,Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences
来源：
Neurochemical Research | 2022年 / 47卷
关键词：
Astrocyte; Autophagy; Neurodegeneration; Cerebral ischemia; Depression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Astrocytes act as “housekeeping cells” for maintaining cerebral homeostasis and play an important role in many disorders. Recent studies further highlight the contribution of autophagy to astrocytic functions, including astrogenesis, the astrocytic removal of neurotoxins or stressors, and astrocytic polarization. More importantly, genetic and pharmacological approaches have provided evidence that outlines the contributions of astrocytic autophagy to several brain disorders, including neurodegeneration, cerebral ischemia, and depression. In this study, we summarize the emerging role of autophagy in regulating astrocytic functions and discuss the contributions of astrocytic autophagy to different CNS disorders.
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页码：3697 / 3708
页数：11
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