Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action

被引:0
作者
Emanuele Rizzo
机构
[1] Local Health Authority of Lecce (ASL Lecce),Department of Prevention
[2] Italian Society of Environmental Medicine (SIMA),undefined
来源
Naunyn-Schmiedeberg's Archives of Pharmacology | 2020年 / 393卷
关键词
Ivermectin; Antiviral; Ionophore; COVID-19; SARS-CoV-2;
D O I
暂无
中图分类号
学科分类号
摘要
Ivermectin is an antiparasitic drug that has shown also an effective pharmacological activity towards various infective agents, including viruses. This paper proposes an alternative mechanism of action for this drug that makes it capable of having an antiviral action, also against the novel coronavirus, in addition to the processes already reported in literature.
引用
收藏
页码:1153 / 1156
页数:3
相关论文
共 135 条
[1]  
Abbott BJ(1979)Microbial transformation of A23187, a divalent cation ionophore antibiotic Antimicrob Agents Chemother. 16 808-812
[2]  
Fukuda DS(2016)Ivermectin exhibits potent anti-mitotic activity Vet Parasitol. 226 1-4
[3]  
Dorman DE(2018)In vitro activity of ivermectin against Staphylococcus aureus clinical isolates Antimicrob Resist Infect Control. 7 27-206
[4]  
Occolowitz JL(1979)Ionophore Antibiotics. In: Hahn F.E. (eds) Mechanism of action of antibacterial agents Antibiotics 5 1-74
[5]  
Debono M(2012)Nuclear trafficking of proteins from RNA viruses: potential target for anti-virals? Antiviral research 95 202-505
[6]  
Farhner L(2020)The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro Antiviral Res. 3 104787-532
[7]  
Ashraf S(2003)Osmotic shock and the strength of viral capsids Biophys J. 85 70-46
[8]  
Prichard R(2017)Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations J Antibiot (Tokyo). 70 495-240
[9]  
Ashraf S(2005)Ivermectin 20 years on: maturation of a wonder drug Trends Parasitol. 21 530-4843
[10]  
Chaudhry U(2008)The pharmacokinetics and interactions of ivermectin in humans--a mini-review AAPS J 10 42-60