Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

被引：0

作者：

Somayeh Keshtkar

Negar Azarpira

Mohammad Hossein Ghahremani

机构：

[1] School of Advanced Technologies in Medicine,Department of Molecular Medicine

[2] Tehran University of Medical Sciences,Department of Pharmacology

[3] Transplant Research Center,Toxicology, Faculty of Pharmacy

[4] Shiraz University of Medical Sciences,undefined

[5] Shiraz Institute of Stem Cell and Regenerative Medicine,undefined

[6] Shiraz University of Medical Sciences,undefined

[7] Tehran University of Medical Sciences,undefined

来源：

Stem Cell Research & Therapy | / 9卷

关键词：

Extracellular vesicles; Mesenchymal stem cells; Regenerative medicine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have made them a key option for tissue repair. The paracrine functions of MSCs are applied through secreting soluble factors and releasing extracellular vesicles like exosomes and microvesicles. Extracellular vesicles are predominantly endosomal in origin and contain a cargo of miRNA, mRNA, and proteins that are transferred from their original cells to target cells. Recently it has emerged that extracellular vesicles alone are responsible for the therapeutic effect of MSCs in plenty of animal diseases models. Hence, MSC-derived extracellular vesicles may be used as an alternative MSC-based therapy in regenerative medicine. In this review we discuss MSC-derived extracellular vesicles and their therapeutic potential in various diseases.

引用

共 428 条

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