Bio-rational design of photosystem II inhibitors (VIII)Molecular design, synthesis and inhibitory activity of acrylates (acrylamides)

被引：0
作者：
Huayin Liu
Yinlin Sha
Huifen Tan
Huazheng Yang
Luhua Lai
机构：
[1] Nankai University,State Key Laboratory and Institute of Elemento
[2] Peking University,Organic Chemistry
来源：
Science in China Series B: Chemistry | 1999年 / 42卷
关键词：
photosystem II; acrylates (acrylamides); molecular modeling; molecular design; Hill reaction inhibitory activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Molecular modeling of acrylates (acrylamides) with Dl protein ofPisum sativum is presented. Studies show that the binding force mainly includes H-bond interaction, Van der Waals and π-ring stacking interaction. It was found that SER 268 in Dl protein might be an important binding site. It is important for high inhibitory activity of compounds whether an electronegative atom in alkyl of ester linkage could make H-bond interaction with SER 268 in Dl protein. Thus some new acrylates (acrylamides) were designed and synthesized. Bioassay indicated that these new compounds showed expected Hill reaction inhibitory activity.
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页码：326 / 331
页数：5
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