Psoriasis is not a risk factor for dementia: a 12-year nationwide population-based cohort study

被引:0
作者
Chen-Yi Wu
Hsiao-Yun Hu
Yiing-Jenq Chou
Chung-Pin Li
Yun-Ting Chang
机构
[1] Taipei Veterans General Hospital,Department of Dermatology
[2] National Yang-Ming University,Department of Public Health, Institute of Public Health
[3] National Yang-Ming University,Department of Dermatology
[4] Taipei City Hospital,Department of Education and Research
[5] Taipei Veterans General Hospital,Division of Gastroenterology and Hepatology, Department of Medicine
[6] National Yang-Ming University School of Medicine,undefined
来源
Archives of Dermatological Research | 2020年 / 312卷
关键词
Psoriasis; Dementia; Cohort study; Phototherapy; Systemic treatment;
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学科分类号
摘要
Studies investigating the risk for dementia in psoriatic patients remain inconclusive. There are a limited number of population-based studies on the association between psoriasis and dementia. This study aims to investigate the risk for dementia in psoriatic patients. This nationwide population-based cohort study was based on data obtained from the Taiwan National Health Insurance Research Database between 2000 and 2012. A total of 111,825 patients with psoriasis and 111,825 age-, sex-, and index date-matched controls were recruited. The hazard ratio (HR) for subsequent dementia in patients with psoriasis was analyzed using a Cox model and a Fine-Gray competing risk model. During 1,358,774 person-years of follow-up, 2688 patients developed dementia in the psoriatic cohort, and 2062 developed dementia in the control cohort. In the multivariate adjusted Cox model, the hazard ratio (HR) of psoriatic patients for dementia was 1.02 [95% confidence interval (CI) 0.96–1.09] relative to the controls. Psoriasis did not increase the risk for dementia (both vascular dementia and degenerative dementia). In the competing risk model, the HR of dementia was 0.96 (95% CI 0.90–1.02) for psoriatic patients. Compared to psoriatic patients who had not received phototherapy or systemic treatment, those psoriatic patients receiving phototherapy or systemic treatment had a lower risk for dementia. However, this phenomenon was not observed in psoriatic patients who were observed for longer than 6 years. Psoriasis was not found to be a risk factor for dementia. Phototherapy and systemic treatment might not have a protective effect against dementia in psoriatic patients.
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页码:657 / 664
页数:7
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  • [1] Burns A(2009)Dementia BMJ 338 b75-1560
  • [2] Iliffe S(2005)Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease Arch Neurol 62 1556-281
  • [3] Kivipelto M(2005)Midlife cardiovascular risk factors and risk of dementia in late life Neurology 64 277-1796
  • [4] Ngandu T(2018)Comorbidity profiles of psoriasis in Taiwan: a latent class analysis PLoS ONE 13 e0192537-332
  • [5] Fratiglioni L(2010)Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions J Invest Dermatol 130 1785-2743
  • [6] Viitanen M(2012)Role of cardiovascular risk factors (CRF) in the patients with mild cognitive impairment (MCI) Arch Gerontol Geriatr 54 330-140
  • [7] Kareholt I(2009)Smoking and psoriasis: from epidemiology to pathomechanisms J Invest Dermatol 129 2741-662
  • [8] Winblad B(2008)Alcohol consumption and psychological distress in patients with psoriasis Br J Dermatol 158 138-440
  • [9] Helkala EL(2013)Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies J Am Acad Dermatol 68 654-419
  • [10] Tuomilehto J(2013)The role of peripheral inflammatory markers in dementia and Alzheimer's disease: a meta-analysis J Gerontol A Biol Sci Med Sci 68 433-85