Brain Maturity and Brain Injury in Newborns With Cyanotic Congenital Heart Disease

被引：0
作者：
Soad A. Shedeed
Eman Elfaytouri
机构：
[1] Zagazig University,Pediatrics Department
[2] Gharian Teaching Hospital,Radiology Department
来源：
Pediatric Cardiology | 2011年 / 32卷
关键词：
Cyanotic congenital heart disease; -acetylaspartate; Newborn; MRS;
D O I：
暂无
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学科分类号：
摘要：
Patients with congenital heart disease (CHD) are at high risk for adverse neurodevelopmental outcomes. The aim of this work was to assess brain maturity and brain injury in newborns with cyanotic CHD using proton magnetic resonance spectroscopy (MRS). The study included 38 newborns with cyanotic CHD (study group) and 20 healthy full-term newborns (control group) matched together regarding gestational age and sex. Three-dimensional MRS showed that the mean ratio of N-acetylaspartate to choline (Ch) was significantly lower in newborns with cyanotic CHD (0.55 ± 0.08) compared with controls (0.67 ± 0.11) (p < 0.001). However, the mean ratio of lactate to Ch metabolite was significantly higher in the studied cases (0.14 ± 0.04) compared with controls (0.09 ± 0.04) (p < 0.001). The mean value for average diffusivity was 1.41 ± 0.06 in newborns with cyanotic CHD compared with 1.27 ± 0.07 in control newborns (p < 0.001), and the mean value for white-matter fractional anisotropy was 0.19 ± 0.03 in cyanotic newborns and 0.25 ± 0.08 in controls (p < 0.001). Newborns with cyanotic CHD are at increased risk of cerebral white matter injury as well as poor brain maturity. MRS provides a surrogate marker for early detection of such brain abnormalities.
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页码：47 / 54
页数：7
相关论文
共 118 条
[1]  
Ballard J(1991)New Ballard score: expanded to include extremely premature infants J Pediatr 119 417-420
[2]  
Khory J(2001)Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report Am J Neuroradiol 22 1786-1794
[3]  
Wedig K(2006)MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy Am J Neuroradiol 27 533-547
[4]  
Wang L(1996)Statistics notes: logarithms Br Med J 4 312-319
[5]  
Eilers-Walsman B(2005)Comparing microstructural and macrostructural development of the cerebral cortex in premature newborns: diffusion tensor imaging versus cortical gyration Neuroimage 27 579-586
[6]  
Lipp R(2005)Developmental changes in diffusion anisotropy coincide with immature oligodendrocyte progression and maturation of compound action potential J Neurosci 25 5988-5997
[7]  
Barkovich AJ(2006)Intermediate-term outcomes of the arterial switch operation for transposition of great arteries in neonates: alive but well? J Thorac Cardiovasc Surg 132 845-852
[8]  
Westmark KD(2006)The relationship of post-operative electrographic seizures to neurodevelopmental outcome at 1 year of age after neonatal and infant cardiac surgery J Thorac Cardiovasc Surg 131 181-189
[9]  
Bedi HS(2009)Ghrelin levels in children with congenital heart disease J Trop Pediatr 55 307-312
[10]  
Partridge JC(1999)Neurologic status of newborns with congenital heart defects before open heart surgery Pediatrics 103 402-408
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