Pharmacokinetic and Pharmacodynamic Interaction between Allopurinol and Probenecid in Healthy Subjects

被引：0
|
作者：
Sophie L. Stocker
Kenneth M. Williams
Andrew J. McLachlan
Garry G. Graham
Richard O. Day
机构：
[1] University of Sydney,Faculty of Pharmacy
[2] St Vincent’s Hospital,Department of Clinical Pharmacology and Toxicology
[3] University of New South Wales,School of Medical Sciences
[4] Concord Hospital,Centre for Education and Research on Ageing
[5] St Vincent’s Hospital,Department of Clinical Pharmacology and Toxicology
来源：
Clinical Pharmacokinetics | 2008年 / 47卷
关键词：
Allopurinol; Probenecid; Benzbromarone; Oxypurinol; Tophaceous Gout;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background and objective: Combination therapy with allopurinol and probenecid is used to treat tophaceous gout in patients who do not respond sufficiently to allopurinol alone. However, the potential interaction between these drugs has not been systematically investigated. The objective of this study was to investigate the pharmacokinetics and hypouricaemic effect of oxypurinol (the active metabolite of allopurinol) and probenecid when administered alone and in combination in healthy subjects.
引用
收藏
页码：111 / 118
页数：7
相关论文
共 50 条
  • [1] Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in healthy subjects
    Stocker, Sophie L.
    Williams, Kenneth M.
    McLachlan, Andrew J.
    Graham, Garry G.
    Day, Richard O.
    CLINICAL PHARMACOKINETICS, 2008, 47 (02) : 111 - 118
  • [2] Pharmacokinetic and Pharmacodynamic Interaction Between Allopurinol and Probenecid in Patients with Gout
    Stocker, Sophie L.
    Graham, Garry G.
    McLachlan, Andrew J.
    Williams, Kenneth M.
    Day, Richard O.
    JOURNAL OF RHEUMATOLOGY, 2011, 38 (05) : 904 - 910
  • [3] ASSESSMENT OF PHARMACOKINETIC INTERACTION BETWEEN PRADIGASTAT AND ATAZANAVIR OR PROBENECID IN HEALTHY SUBJECTS
    Mendonza, A.
    Meyers, D.
    Koo, P.
    Neelakantham, S.
    Majumdar, T.
    Rebello, S.
    Sunkara, G.
    Chen, J.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 95 : S79 - S79
  • [4] Pharmacokinetic and Pharmacodynamic Interaction Between Tolvaptan and Warfarin in Healthy Subjects
    Shoaf, Susan E.
    Mallikaarjun, Suresh
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2012, 1 (02): : 67 - 75
  • [5] Pharmacokinetic and Pharmacodynamic Interaction Between Gemigliptin and Metformin in Healthy Subjects
    Dongseong Shin
    Young Min Cho
    SeungHwan Lee
    Kyoung Soo Lim
    Jeong-Ae Kim
    Ji-Yung Ahn
    Joo-Youn Cho
    Howard Lee
    In-Jin Jang
    Kyung-Sang Yu
    Clinical Drug Investigation, 2014, 34 : 383 - 393
  • [6] Pharmacokinetic and Pharmacodynamic Interaction Between Gemigliptin and Metformin in Healthy Subjects
    Shin, Dongseong
    Cho, Young Min
    Lee, SeungHwan
    Lim, Kyoung Soo
    Kim, Jeong-Ae
    Ahn, Ji-Yung
    Cho, Joo-Youn
    Lee, Howard
    Jang, In-Jin
    Yu, Kyung-Sang
    CLINICAL DRUG INVESTIGATION, 2014, 34 (06) : 383 - 393
  • [7] INTERACTION OF PROBENECID AND ALLOPURINOL IN GOUTY SUBJECTS
    TJANDRAM.TB
    CUCINELL, SA
    FEDERATION PROCEEDINGS, 1971, 30 (02) : A392 - &
  • [8] Pharmacokinetic and pharmacodynamic aspects of the interaction between clazosentan and nimodipine in healthy subjects
    van Giersbergen, P. L. M.
    Dingemanse, J.
    CEREBRAL VASOSPASM: NEW STRATEGIES IN RESEARCH AND TREATMENT, 2008, 104 : 127 - 130
  • [9] Pharmacokinetic/Pharmacodynamic Interaction Between Evogliptin and Pioglitazone in Healthy Male Subjects
    Hwang, Inyoung
    Kim, Yun
    Yoo, Hyounggyoon
    Jang, In-Jin
    Yu, Kyung-Sang
    Lee, SeungHwan
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 14 : 4493 - 4502
  • [10] Pharmacokinetic and pharmacodynamic interaction between ezetimibe and rosuvastatin in healthy male subjects
    Kim, Chang Hee
    An, Hyungmi
    Kim, Sung Hye
    Shin, Dongseong
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2017, 11 : 3461 - 3469
12345