Non-Hodgkin lymphomas of the oral cavity in AIDS patients in a reference hospital of infectious diseases in Argentina: Report of eleven cases and review of the literature

被引：12

作者：

Corti M. ^{[1
]}

Villafañe M.F. ^{[1
]}

Solari R. ^{[1
]}

De Carolis L. ^{[1
]}

Cangelosi D. ^{[1
]}

Santoro J. ^{[1
]}

Schtirbu R. ^{[1
]}

Lewi D. ^{[2
]}

Bistmans A. ^{[3
]}

Narbaitz M. ^{[4
]}

Baré P. ^{[4
]}

机构：

[1] Division B, Infectious Diseases F. J. Muñiz Hospital, 1406 CQG, Buenos Aires

[2] Juan A. Fernández Hospital, Buenos Aires

[3] Ramos Mejía Hospital, Buenos Aires

[4] National Academy of Medicine, Buenos Aires

来源：

Journal of Gastrointestinal Cancer | 2011年 / 42卷 / 3期

关键词：

AIDS; EBV; HHV-8; Oral cavity lymphoma; Plasmablastic lymphoma;

D O I：

10.1007/s12029-010-9173-9

中图分类号：

学科分类号：

摘要：

Introduction: Extranodal non-Hodgkin lymphoma (NHL) were commonly described in AIDS patients and are related with an atypical morphology and aggressive clinical course. Materials and Methods: In this single institutional study we evaluated the epidemiological, clinical, immunological, virological, histopathological and the outcome of eleven HIV/AIDS patients with oral cavity lymphomas (OCL). Results: Nine were males and seven intravenous drug abusers. The median of age was 33 years and the median of CD4 T cell counts at the time of diagnosis was 97 cell/μL. The majority of tumors presented as large and ulcerated masses involving the gingiva, the palate and the jaw. Six of these tumors were diffuse large B-cell lymphomas (DLBCL); three were Burkitt's lymphomas and the final case was a plasmablastic lymphoma. An association with Epstein-Barr virus (EBV) was found in three of the ten tested cases by in situ hybridization (EBER 1 and 2 probes) and immunohistochemistry (LMP-1). Human herpes virus-8 (HHV-8) was detected by polymerase chain reaction (PCR) in only one neoplasm. Six patients died without specific treatment; four received chemotherapy and highly active antiretroviral therapy (HAART) and three of them presented a prolonged survival. Discussion Combination: of HAART and chemotherapy should modify the poor prognosis of AIDS patients with OCL. © Springer Science+Business Media, LLC 2010.

引用

页码：143 / 148

页数：5

共 17 条

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