Hexokinase 2 is dispensable for T cell-dependent immunity

被引:0
作者
Manan M. Mehta
Samuel E. Weinberg
Elizabeth M. Steinert
Krishan Chhiba
Carlos Alberto Martinez
Peng Gao
Harris R. Perlman
Paul Bryce
Nissim Hay
Navdeep S. Chandel
机构
[1] Northwestern University Feinberg School of Medicine,Department of Medicine
[2] Northwestern University Feinberg School of Medicine,Department of Biochemistry and Molecular Genetics
[3] Northwestern University Robert H. Lurie Comprehensive Cancer Center,Metabolomics Core Facility
[4] University of Illinois at Chicago,Department of Biochemistry and Molecular Genetics
来源
Cancer & Metabolism | / 6卷
关键词
Hexokinase 2; T cells; Tregs; Leukemia; Colitis; LCMV;
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[1]  
Pearce EL(2013)Fueling immunity: insights into metabolism and lymphocyte function Science 342 1242454-70
[2]  
Poffenberger MC(2016)Fundamentals of cancer metabolism Sci Adv 2 e1600200-464
[3]  
Chang CH(2017)Similarities and distinctions of cancer and immune metabolism in inflammation and tumors Cell Metab 26 49-1251
[4]  
Jones RG(2011)Aerobic glycolysis: meeting the metabolic requirements of cell proliferation Annu Rev Cell Dev Biol 27 441-54
[5]  
DeBerardinis RJ(2013)Posttranscriptional control of T cell effector function by aerobic glycolysis Cell 153 1239-2134
[6]  
Chandel NS(2015)The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo Immunity 42 41-705
[7]  
Andrejeva G(2015)Normalization of CD4+ T cell metabolism reverses lupus Sci Transl Med 7 274ra218-3303
[8]  
Rathmell JC(2013)Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells J Exp Med 210 2119-173
[9]  
Lunt SY(1976)Aerobic glycolysis during lymphocyte proliferation Nature 261 702-608
[10]  
Vander Heiden MG(2011)Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets J Immunol 186 3299-1241