Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells

被引：0

作者：

Frida Nikesjö

Shumaila Sayyab

Lovisa Karlsson

Eirini Apostolou

Anders Rosén

Kristofer Hedman

Maria Lerm

机构：

[1] Linköping University,Department of Respiratory Medicine in Linköping, Department of Biomedical and Clinical Sciences

[2] Linköping University,Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences

[3] Linköping University,Division of Cell Biology, Department of Biomedical and Clinical Sciences

[4] Linköping University,Department of Clinical Physiology, Department of Health, Medicine and Caring Sciences

来源：

Clinical Epigenetics | 2022年 / 14卷

关键词：

Post-acute COVID-19 syndrome; PACS; COVID-19; SARS-CoV-2; PBMC; Epigenetics; DNA methylation; Biosignature;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Post-acute COVID-19 syndrome (PACS) has been defined as symptoms persisting after clearance of a COVID-19 infection. We have previously demonstrated that alterations in DNA methylation (DNAm) status persist in individuals who recovered from a COVID-19 infection, but it is currently unknown if PACS is associated with epigenetic changes. We compared DNAm patterns in patients with PACS with those in controls and in healthy COVID-19 convalescents and found a unique DNAm signature in PACS patients. This signature unravelled modified pathways that regulate angiotensin II and muscarinic receptor signalling and protein–protein interaction networks that have bearings on vesicle formation and mitochondrial function.

引用

共 50 条

[41] Post-acute COVID-19 syndrome and kidney diseases: what do we know? [J].

Sidar Copur ;

Metehan Berkkan ;

Carlo Basile ;

Katherine Tuttle ;

Mehmet Kanbay .

Journal of Nephrology, 2022, 35 :795-805

[42] Neutrophil Gelatinase-Associated Lipocalin as a Biomarker in Post-Acute COVID-19 Syndrome [J].

Zmudka, Karol ;

Galeczka-Turkiewicz, Alicja ;

Wroniecka, Aleksandra ;

Wlosowicz, Aleksandra ;

Sobala-Szczygiel, Barbara ;

Mrochem-Kwarciak, Jolanta ;

Czuba, Zenon P. ;

Jaroszewicz, Jerzy .

JOURNAL OF CLINICAL MEDICINE, 2024, 13 (07)

[43] Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus [J].

Raman, Betty ;

Bluemke, David A. ;

Luescher, Thomas F. ;

Neubauer, Stefan .

EUROPEAN HEART JOURNAL, 2022, 43 (11) :1157-+

[44] Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus [J].

Raman, Betty ;

Bluemke, David A. ;

Luscher, Thomas F. ;

Neubauer, Stefan .

EUROPEAN HEART JOURNAL, 2022,

[45] Reduction in ACE2 expression in peripheral blood mononuclear cells during COVID-19-implications for post COVID-19 conditions [J].

Ahmed, Gulrayz ;

Abdelgadir, Yasir ;

Abdelghani, Amro ;

Simpson, Pippa ;

Barbeau, Jody ;

Basel, Donald ;

Barrios, Christy S. ;

Smith, Brandon A. ;

Schilter, Kala F. ;

Udani, Rupa ;

Reddi, Honey V. ;

Willoughby, Rodney E. .

BMC INFECTIOUS DISEASES, 2024, 24 (01)

[46] Incomplete Systemic Recovery and Metabolic Phenoreversion in Post-Acute-Phase Nonhospitalized COVID-19 Patients: Implications for Assessment of Post-Acute COVID-19 Syndrome [J].

Holmes, Elaine ;

Wist, Julien ;

Masuda, Reika ;

Lodge, Samantha ;

Nitschke, Philipp ;

Kimhofer, Torben ;

Loo, Ruey Leng ;

Begum, Sofina ;

Boughton, Berin ;

Yang, Rongchang ;

Morillon, Aude-Claire ;

Chin, Sung-Tong ;

Hall, Drew ;

Ryan, Monique ;

Bong, Sze-How ;

Gay, Melvin ;

Edgar, Dale W. ;

Lindon, John C. ;

Richards, Toby ;

Yeap, Bu B. ;

Pettersson, Sven ;

Spraul, Manfred ;

Schaefer, Hartmut ;

Lawler, Nathan G. ;

Gray, Nicola ;

Whiley, Luke ;

Nicholson, Jeremy K. .

JOURNAL OF PROTEOME RESEARCH, 2021, 20 (06) :3315-3329

[47] Factors Associated with Severe COVID-19 and Post-Acute COVID-19 Syndrome in a Cohort of People Living with HIV on Antiretroviral Treatment and with Undetectable HIV RNA [J].

Mazzitelli, Maria ;

Trunfio, Mattia ;

Sasset, Lolita ;

Leoni, Davide ;

Castelli, Eleonora ;

Lo Menzo, Sara ;

Gardin, Samuele ;

Putaggio, Cristina ;

Brundu, Monica ;

Garzotto, Pietro ;

Cattelan, Anna Maria .

VIRUSES-BASEL, 2022, 14 (03)

[48] The ambulatory care of patients with post-acute sequelae of COVID-19 [J].

Christoph Strumann ;

Wolfgang C. G. von Meißner ;

Paul-Georg Blickle ;

Jost Steinhäuser .

Research in Health Services & Regions, 2 (1)

[49] Hemophagocytic Lymphohistiocytosis in a Patient With Post-acute COVID-19 Infection [J].

Jiffry, Mohamed Zakee Mohamed ;

Ahmed-Khan, Mohammed ;

Vargas, Jonathan ;

Thomas, Teena ;

Josey, Susanna .

CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (11)

[50] Acute tubulointerstitial nephritis with or without uveitis: a novel form of post-acute COVID-19 syndrome in children [J].

Avramescu, Marina ;

Isnard, Pierre ;

Temmam, Sarah ;

Chevalier, Agnes ;

Bastard, Paul ;

Attia, Mikael ;

Berthaud, Romain ;

Fila, Marc ;

Dossier, Claire ;

Hogan, Julien ;

Ulinski, Tim ;

Leguevaques, Damia ;

Louillet, Ferielle ;

Casado, Edouard Martinez ;

Halimi, Jean-Michel ;

Cloarec, Sylvie ;

Zaloszyc, Ariane ;

Faudeux, Camille ;

Rousset-Rouviere, Caroline ;

Clave, Stephanie ;

Harambat, Jerome ;

Rollot, Edouard ;

Simon, Thomas ;

Nallet-Amate, Megan ;

Ranchin, Bruno ;

Bacchetta, Justine ;

Porcheret, Florence ;

Bernard, Josselin ;

Ryckewaert, Amelie ;

Jamet, Anne ;

Fourgeaud, Jacques ;

Da Rocha, Nicolas ;

Perot, Philippe ;

Kuperwasser, Nicolas ;

Bouazza, Naim ;

Rabant, Marion ;

Van Huyen, Jean-Paul Duong ;

Robert, Matthieu P. ;

Zuber, Julien ;

Casanova, Jean-Laurent ;

Eloit, Marc ;

Sermet-Gaudelus, Isabelle ;

Boyer, Olivia .

KIDNEY INTERNATIONAL, 2023, 103 (06) :1193-1198

← 1 2 3 4 5 →