C-phycocyanin Mitigates Cognitive Impairment in Doxorubicin-Induced Chemobrain: Impact on Neuroinflammation, Oxidative Stress, and Brain Mitochondrial and Synaptic Alterations

被引：0
作者：
Chenying Wang
Yuhang Zhao
Lewei Wang
Shunji Pan
Yumei Liu
Sanqiang Li
Dongmei Wang
机构：
[1] Henan University of Science and Technology,School of Basic Medical Sciences
[2] First Affiliated Hospital of Henan University of Science and Technology,Department of Clinical Laboratory Science
[3] Hangzhou Medical College,College of Animal Science and Technology
[4] Henan University of Science and Technology,undefined
[5] Henan Centre for Engineering and Technology Research On Prevention and Treatment of Liver Diseases,undefined
来源：
Neurochemical Research | 2021年 / 46卷
关键词：
C-phycocyanin; Chemotherapy; Cognitive; Mitochondria; Doxorubicin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chemotherapy-induced cognitive impairment (CICI) is a common detrimental effect of cancer treatment, occurring in up to 75% of cancer patients. The widely utilized chemotherapeutic agent doxorubicin (DOX) has been implicated in cognitive decline, mostly via cytokine-induced neuroinflammatory and oxidative and mitochondrial damage to brain tissues. C-phycocyanin (CP) has previously been shown to have potent anti-inflammatory, antioxidant, and mitochondrial protective properties. Therefore, this present study was aimed to investigate the neuroprotective effects of CP against DOX-elicited cognitive impairment and explore the underlying mechanisms. CP treatment (50 mg/kg) significantly improved behavioral deficits in DOX-treated mice. Furthermore, CP suppressed DOX-induced neuroinflammation and oxidative stress, mitigated mitochondrial abnormalities, rescued dendritic spine loss, and increased synaptic density in the hippocampus of DOX-treated mice. Our results suggested that CP improves established DOX-induced cognitive deficits, which could be explained at least partly by inhibition of neuroinflammatory and oxidant stress and attenuation of mitochondrial and synaptic dysfunction.
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页码：149 / 158
页数：9
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