Influence of different CLA isomers on insulin resistance and adipocytokines in pre-diabetic, middle-aged men with PPARγ2 Pro12Ala polymorphism

被引：0

作者：

Diana Rubin

Julia Herrmann

Daniela Much

Maria Pfeuffer

C. Laue

P. Winkler

Ulf Helwig

Doris Bell

Annegret Auinger

Stephanie Darabaneanu

Andreas Ruether

Jürgen Schrezenmeir

机构：

[1] Max Rubner Institute,Department of Physiology and Biochemistry of Nutrition

[2] Federal Institute for Risk Assessment,Department of Food Safety

[3] Dr. von Hauner Children’s Hospital,Division of Metabolic and Nutritional Medicine

[4] University of Munich Medical Centre,Department of Physiology and Biochemistry of Nutrition

[5] Center of Clinical Research,Department of Physiology and Biochemistry of Nutrition

[6] Tecura GmbH,undefined

[7] Project Management Agency at German Aerospace Center,undefined

[8] Institute of Medical Psychology,undefined

[9] University Clinic of Kiel,undefined

[10] Institute of Clinical Molecular Biology,undefined

[11] Christian-Albrechts-University of Kiel,undefined

[12] Max Rubner Institute,undefined

[13] Max Rubner Institute,undefined

来源：

Genes & Nutrition | 2012年 / 7卷

关键词：

CLA; PPAR Pro12Ala; Metabolic syndrome; Insulin; Insulin resistance; HOMA; Postprandial; Diabetes; Nutrigenetic; Gene–nutrient interaction; Adiponectin; Adipocytokines; Triglycerides;

D O I：

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学科分类号：

摘要：

Conjugated linoleic acids (CLAs) are natural PPARγ ligands, which showed conflicting effects on metabolism in humans. We examined metabolic effects of different isomers of CLA in subjects with PPARγ2 Pro12Ala polymorphisms. A total of 35 men underwent four intervention periods in a crossover study design: subjects with either genotypes received c9, t11 CLA or t10, c12 CLA, a commercially available 1:1 mix of both isomers or reference oil (linoleic acid (LA)). Adipocytokines, insulin, glucose and triglycerides were assessed in the fasting state and after a standardized mixed meal. Across all genotypes, there was a significant (p = 0.025) CLA treatment effect upon postprandial (pp) HOMA-IR values, with c9, t11 CLA and CLA isomer mix improving, but t10, c12 CLA isomer worsening. In Ala12Ala subjects, the t10, c12 isomer caused weight gain (p = 0.03) and tended to increase postprandial insulin levels (p = 0.05). In Pro12Pro subjects, t10, c12 resulted in reduction in waist circumference (p = 0.03). The comparison of the different genotype groups revealed statistically different changes in fasting and postprandial insulin, HOMA-IR and leptin after intervention. c9, t11 CLA and the commercial CLA mix showed beneficial effects on insulin sensitivity compared with LA, while t10, c12 CLA adversely affects body weight and insulin sensitivity in different PPAR genotypes. CLA isomers have different effects on metabolism in Ala and Pro carriers.

引用

页码：499 / 509

页数：10

共 220 条

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