The peculiar genetics of the ribosomal DNA blurs the boundaries of transgenerational epigenetic inheritance

被引：0
作者：
Farah Bughio
Keith A. Maggert
机构：
[1] University of Arizona,Department of Cellular and Molecular Medicine, College of Medicine
[2] University of Arizona College of Medicine,University of Arizona Cancer Center
来源：
Chromosome Research | 2019年 / 27卷
关键词：
rDNA; Ribosomal DNA; Epigenetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Our goal is to draw a line—hypothetical in its totality but experimentally supported at each individual step—connecting the ribosomal DNA and the phenomenon of transgenerational epigenetic inheritance of induced phenotypes. The reasonableness of this hypothesis is offset by its implication, that many (or most) (or all) of the cases of induced-and-inherited phenotypes that are seen to persist for generations are instead unmapped induced polymorphisms in the ribosomal DNA, and thus are the consequence of the peculiar and enduringly fascinating genetics of the highly transcribed repeat DNA structure at that locus.
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页码：19 / 30
页数：11
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