Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine

被引：0
作者：
Lijun Chen
Jingjing Qu
Quanhui Mei
Xin Chen
Yangxin Fang
Lu Chen
Yifei Li
Charlie Xiang
机构：
[1] Zhejiang University,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated
[2] Zhejiang University,Department of Respiratory Disease, Thoracic Disease Centre, The First Affiliated Hospital, College of Medicine
[3] The First People’s Hospital of Changde City,Department of Intensive Care Unit
[4] Innovative Precision Medicine (IPM) Group,undefined
来源：
Stem Cell Research & Therapy | / 12卷
关键词：
Menstrual blood-derived mesenchymal stem cell (MenSC); Small extracellular vesicle; Exosomes; Cell-free therapy; Regenerative medicine;
D O I：
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学科分类号：
摘要：
Menstrual blood-derived mesenchymal stem cells (MenSCs) have great potential in regenerative medicine. MenSC has received increasing attention owing to its impressive therapeutic effects in both preclinical and clinical trials. However, the study of MenSC-derived small extracellular vesicles (EVs) is still in its initial stages, in contrast to some common MSC sources (e.g., bone marrow, umbilical cord, and adipose tissue). We describe the basic characteristics and biological functions of MenSC-derived small EVs. We also demonstrate the therapeutic potential of small EVs in fulminant hepatic failure, myocardial infarction, pulmonary fibrosis, prostate cancer, cutaneous wound, type-1 diabetes mellitus, aged fertility, and potential diseases. Subsequently, novel hotspots with respect to MenSC EV-based therapy are proposed to overcome current challenges. While complexities regarding the therapeutic potential of MenSC EVs continue to be unraveled, advances are rapidly emerging in both basic science and clinical medicine. MenSC EV-based treatment has great potential for treating a series of diseases as a novel therapeutic strategy in regenerative medicine.
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